FWD 1 American Botanical Council: The ABC Clinical Guide to Herbs

Recent Studies

In consideration of the continuously developing nature of medical and scientific information, we have created this section to provide citations for several significant studies that, due to their release immediately prior to the printing of this book, were not included in the corresponding monographs. For further information regarding new research developments and breaking news in the industry since the publication of this book in April 2003, the reader is referred to other areas of ABC’s website such as HerbalGram and HerbClip.

Asian Ginseng

Coon JT, Ernst E. Panax ginseng: a systematic review of adverse effects and drug interactions. Drug safety 2002;25(5):323–44.
Hong B, Ji YH, Nam KY, Ahn TY. A double-blind crossover study evaluating the efficacy of Korean red ginseng in patients with erectile dysfunction: a preliminary report. J Urol 2002;168:2070–3.

Black Cohosh

Bodinet C, Freudenstein J. Influence of Cimicifuga racemosa on the proliferation of estrogen receptor-positive human breast cancer cells. Breast Cancer Res Treat 2002;76:1–10.
Borrelli F, Ernst E. Cimicifuga racemosa: A systematic review of its clinical efficacy. Eur J Clin Pharmacol 2002;58:235–41.
Freudstein J, Dasenbrock C, Niβlein T. Lack of promotion of estrogen-dependent mammary gland tumor in vivo by an isopropanolic Cimicifuga racemosa extract. Cancer Res 2002;62:3448–52.
Kennelly EJ, Baggett S, Nuntanakorn P, Ososki AL, Mori SA, Duke J, et al. Analysis of thirteen populations of black cohosh for formononetin. Phytomedicine 2002;9(5):461–7.
Kronenberg F, Fugh-Berman A. Complementary and alternative medicine for menopausal symptoms: a review of randomized, controlled trials. Ann Intern Med 2002;137(10):805–14.
Liske E, Hänggi W, Henneicke-Von Zepelin HH, Boblitz N, Wüstenberg P, Rahlfs VW. Physiological investigation of a unique extract of black cohosh (Cimicifuga racemosa rhizoma): a 6-month clinical study demonstrates no systemic estrogenic effect. J Womens Health and Gend Based Med 2002;11(2):163–74.
Zierau O, Bodinet C, Kolba S, Wulf M, Vollmer G. Antiestrogenic activities of Cimicifuga racemosa extracts.
J Steroid Biochem Mol Biol 2002;80:125–30.

Cat’s Claw

Pero RW, Giampapa V, Vojdani A. Comparison of a broad spectrum anti-aging nutritional supplement with and without the addition of DNA repair enhancing cat’s claw extract. J Antiaging Medicine 2002;(5)2:[in press].

Cranberry

Leahy M, Speroni J, Starr M. Latest developments in cranberry health research. Pharmaceutical Biology 2002;4 Suppl:50–4.
Terris MK, Issa MM, Tacker JR. Dietary supplementation with cranberry concentrate tablets may increase the risk of nephrolithiasis. Urology 2001;57(1):26–9.
University of Bonn, Germany. Cranberries and blackcurrants combat kidney stones. European J Clin Nutr 2002;51(2):283–5.

Echinacea

Barrett BP, Brown RL, Locken K, Maberry R, Bobula JA, D’Alessio D. Treatment of the common cold with unrefined echinacea: a randomized, double-blind, placebo-controlled trial. Ann Intern Med 2002;137(12):939–46.
Turner, RB. Echinacea for the common cold: can alternative medicine be evidence-based medicine [editorial]. Ann Intern Med 2002;137(12):1001–2.

Ephedra

Bailes JE, Cantu RC, Day AL. The neurosurgeon in sport: awareness of the risks of heatstroke and dietary supplements. Neurosurgery 2002;51(2):283–5.

Ginkgo

Birks J, Grimley EJ, Van Dongen M. Ginkgo biloba for cognitive impairment and dementia [Cochrane Review]. In: The Cochrane Library, Issue 4, 2002. Oxford. Update Software.
Evans JR. Ginkgo biloba extract for age-related macular degeneration [Cochrane Review]. In: The Cochrane Library, Issue 4, 2002. Oxford: Update Software.
Hackett P, Roach R. High-altitude illness. New Engl J Med 2001;345(2):107–14.
Maakestad K, Leadbetter G, Olson S, Hackett P. Ginkgo biloba reduces incidence and severity of acute mountain sickness [abstract]. In: Abstracts from the Wilderness Medical Society’s annual scientific meeting. Cited in: Wildrns and Envir Med 2001;12:51.
Mix JA, Crews WD. A double-blind, placebo-controlled, randomized trial of Ginkgo biloba extract Egb 761 in a sample of cognitively intact older adults: neuropsychological findings. Hum Psychopharmacol Clin Exp 2002;17:267–77.
Morgenstern C, Biermann E. The efficacy of ginkgo special extract EGb 761 in patients with tinnitus. Int J Clin Pharmacol Ther 2002;40(5):188–97.

Kava

Loew D. Kava kava extract: risks, benefits or a problem of society? [in German]. Dtsch Apoth Ztg 2002;142(9):64–74.
Matthews JM, Etheridge AS, Black SR. Inhibition of human cytochrome P450 activities by kava extract and kavalactones. Drug Metab Dispos 2002;30(11):1153–7.

Milk Thistle

Piscitelli SC, Formentini E, Burstein AH, Alfaro R, Jagannatha S, Falloon J. Effect of milk thistle on the pharmacokinetics of Indinavir in healthy volunteers. Pharmacotherapy 2002;22(5):551–6.
Venkatarmanan R, Ramachandran V, Komoroski BJ, Zhang S, Sciff PL, Strom SC. Milk thistle, a herbal supplement, decreases the activity of CYP3A4 and uridine diphosphoglucuronosyl transferase in human hepatocyte cultures. Drug Metab Dispos 2000;28(11):1270–3.

Peppermint

Nair B. Final report on the safety assessment of Mentha piperita (peppermint) oil, Mentha piperita (peppermint) leaf extract, Mentha piperita (peppermint) leaf, and Mentha piperita (peppermint) leaf water. Int J Toxicol 2001;20 Suppl 3:61–73.

Pycnogenol®

Hosseini S, Pishnamazi S, Sadrzadeh SMH, Farid F, Farid R, Watson RR. Pycnogenol® in the management of asthma. Jour Med Food 2001;4(4):201–9.
Kimbrough C, Chun M, dela Roca G, Lau BHS. Pycnogenol® chewing gum minimizes gingival bleeding and plaque formation. Phytomedicine 2002;9:410–13.
Natural Health Science. Significant increase in men’s fertility possible with 90-day Pycnogenol® treatment, study shows [press release]. 2002 Sept 20.
Roseff SJ. Improvement in sperm quality and function with French maritime pine tree bark extract. J Reprod Med 2002;47(10):821–4.

St. John’s Wort

Lecrubier Y, Clerc G, Didi R, Kieser M. Efficacy of St. John’s wort extract WS 5570 in major depression: a double-blind, placebo-controlled trial. Am J Psychiatry 2002;159(8):1361–6.
Van Gurp G, Meterissian GB, Haiek LN, McCusker J, Bellavance F. St. John’s wort or sertraline?: randomized controlled trial in primary care. Can Fam Physician 2002;48:905–12.


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