References for Proprietary Products

Alder D [BotanicLab]. Personal communication to M Blumenthal, Mar. 13, 2002.

Albrecht M, Berger W, Laux P, Schmidt U, Martin C. Psychopharmaceuticals and traffic safety: The influence of Euvegal® forte sugar-coated tablets on driving ability and combination effect with alcohol. Z Allg Med 1995;71:1215–25.

Ammer K, Melnizky P. Medicinal baths for treatment of generalized fibromyalgia [in German]. Forsch Komplementarmed 1999;6:80–5.

Anonymous. Sinupret® for sinusitis and inflammation of the respiratory tract. (manufacturer’s booklet). Neumarkt, Germany: Bionorica Arzneimittel GmbH.

Anonymous. Various studies show Hochu-ekki-to® is effective in aiding recovery. Kampo Today 2001;4(2):1–3,6.

Arcangeli R. Pycnogenol in chronic venous insufficiency. Fitoterapia 2000;71(3):236–44.

Atal CK, Dubey RK, Singh J. Biochemical basis of enhanced drug bioavailability by piperine: evidence that piperine is a potent inhibitor of drug metabolism. J Pharmacol Exp Ther 1985;232(1):258–62.

Atal CK, Zutshi U, Rao PG. Scientific evidence on the role of Ayurvedic herbals on bioavailability of drugs. J Ethnopharmacol 1981;4(2):229–32.

Badmaev VV, Majeed M, Prakash L. Piperine derived from black pepper increases the plasma levels of coenzyme q10 following oral supplementation. J Nutr Biochem 2000;11(2):109–13.

Bahrman N, Zivy M, Damerval C, Baradat P. Organisation of the variability of abundant proteins in seven geographical origins of maritime pine (Pinus pinaster Ait.). Theoretical & Applied Genetics 1994;88(3–4):407–11.

Bano G, Raina RK, Zutshi U, Bedi KL, Johri RK, Sharma SC. Effect of piperine on bioavailability and pharmacokinetics of propranolol and theophylline in healthy volunteers. Eur J Clin Pharmacol 1991;41(6):615–7.

Baumann D, Focke G, Kornosoff G. Phytodolor® bei patienten mit aktivierter gonarthrosse, koxanthrose bzw. Schulter-Arm-Syndrom. Multizentrische randomisierte doppelblindstudie versus Diclofenac-Natrium. Steigerwald, Gmbh. Interner Forschungsbericht 1989.

Bensoussan A, Talley NJ, Hing M, et al. Treatment of irritable bowel syndrome with Chinese herbal medicine. JAMA 1998;280(18):1585–9.

Bernhardt M, Keimel A, Belucci G, Spasojevic P. Doppelblinde, randomisierte vergleich von Phytodolor® N und placebo sowie offener vergleich zu felden 20 tabs bei stationaren kurpatienten mit arthrotischen GelenkverSnderungen [in German]. Unpublished trial, Steigerwald, Germany, 1990.

Bernhardt M, Keimel A, Belucci G, Spasojevic P. Doppelblinde, randomisierte vergleichstudie von Phytodol® N und placebo sowie offener vergleich zu felden 20 tabs bei stationaren kurpatienten mit arthrotischen GelenkverSnderungen [in German]. Unpublished trial, Steigerwald, Germany, 1991.

Blazsó G, Gábor M, Rohdewald P. Anti-inflammatory activities of procyanidin-containing extracts from Pinus pinaster Ait. after oral and cutaneous application. Pharmazie 1997;52(5):380–2.

Blazsó G, Gábor M, Sibbel R, Rohdewald P. Anti-inflammatory and superoxide radical scavenging activities of procyanidin-containing extracts from the bark of Pinus pinaster Sol. and its fractions. Pharm Pharmacol Lett 1994;3:217–20.

Blazsó G, Gaspar R, Gábor M, Rüve H-J, Rohdewald P. ACE inhibition and hypotensive effect of procyanidins containing extract from the bark of Pinus pinaster Sol. Pharm Pharmacol Lett 1996;6(1):8–11.

Blazsó G, Rohdewald P, Sibbel R, Gábor M. Anti-inflammatory activities of procyanidin-containing extracts from Pinus pinaster Sol. In: Antus S, Gábor M, Vetschera K, editors. Proceedings of the International Bioflavonoid Symposium; 1995 July 16–19; Vienna, Austria; 1995. p. 231–8.

Blumenthal M. Herb sales down 15% in mainstream market. HerbalGram 2001;51:69.

Blumenthal M, Busse WR, Goldberg A, Gruenwald J, Hall T, Riggins CW, Rister
RS editors. Klein S, Rister RS (trans.). The Complete German Commission E
Monographs—Therapeutic Guide to Herbal Medicines. Austin (TX): American
Botanical Council; Boston (MA): Integrative Medicine Communication; 1998.

Bos R, Hendriks H, Scheffer J, Woerdenbag H. Cytotoxic potential of valerian constituents and valerian tinctures. Phytomedicine 1998;5:219–25.

Braeckow R, Eickstedt K, Kuhne U. Effects of chlorpromazine and valtratum on ethanol anesthesia and ethanol blood level. Arzneimittelforschung 1972;22:1977–80.

Braum D, März R. Randomised, open comparative study of sinupret versus n-acetylcysteine in cases of sinusitis. Bundeswehrkrankenhaus (military hospital), Giessen. 1990.

Brinker F. Herb Contraindications and Drug Interactions, 3d ed. Sandy (OR): Eclectic Institute;2001.

Buz’Zard AR, Peng Q, Lau BH. Kyolic® and Pycnogenol® increase human growth hormone secretion in genetically-engineered keratinocytes. Growth Horm & IGF Res 2002;12(1):34–40.

California State Dept. Human Services, Food and Drug Branch. State health director warns consumers about prescription drugs in herbal products. Feb 7, 2002. Available from URL: http://www.dhs.ca.gov.

Chan T. An assessment of the delayed effects associated with valerian overdose [letter]. Int J Clin Pharmacol Ther 1998;36:569.

Chan T, Tang C, Critchley J. Poisoning due to an over-the-counter hypnotic sleep-Qik (hyoscine, cyproheptadine, valerian). Postgrad Med J 1995;71:227–8.

Chandler RF, Freeman L, Hooper SN. Herbal remedies of the maritime Indians. J Ethnopharmacology 1979;1(1):49–68.

Chauhan BL, Kulkarni RD. Liv.52 in alcoholic liver diseases: a profile of an herbal remedy. Eur J Clin Pharmacol 1991;40(2):189–91.

Cheshier JE, Ardestani-Kaboudanian S, Liang B, Araghiniknam M, Chung S, Lane L, et al. Immuno-modulation by Pycnogenol in retrovirus-infected or ethanol-fed mice. Life Sci 1996;58(5):87–96.

Crates E. Pycnogenol– barking up the right tree. Funct Foods & Nutraceuticals 2000;3(13):16–7.

Dharmananda S. The nature of ginseng: traditional use, modern research, and the question of dosage. HerbalGram 2002;54:34–51.

Dietary Supplement Health and Education Act of 1994 (DSHEA), Public Law 103-417, 21 USC § 3419.

Doucet M, Durand-Cagniart MO, Tanger-Rubin M. The value of FLAVAN for functional symptoms and the prevention of venous insufficiency. Act Méd Int 1987;4(59):2–4.

Drabaek H, Mehlsen J, Himmelstrup H, Winther K. A botanical compound, Padma® 28, increases walking distance in stable intermittent claudication. Angiology 1993;44(11):863–7.

Dressing H, Köhler S, Müller WE. Improvement of sleep quality with a high-dose valerian/lemon balm preparation: a placebo-controlled double-blind study. Psychopharma 1996;3:123–30.

Dressing H, Riemann D, Löw H, et al. Insomnia: are valerian/balm combinations of equal value to bezodiazepine? Therapiewoche, 42 1992 Mar;12:726–736.

DSHEA. See: Dietary Supplement Health and Education Act of 1994.

Dutkeiwicz T, Samochowiec L, Wójcicki J. Padma 28® modifies immunological functions in experimental atherosclerosis in rabbits. Archivum Immunologiae et Therapiae Experimentalis 1992;40:291–5.

Egetenmaier J, März R. Double-blind study of Sinupret drops versus ambroxol drops in acute uncomplicated (tracheo-) bronchitis. 1991.

Elstner E, Kleber E. Radical scavenger properties of leucocyanidine. Proceedings of the 3rd International Symposium on Flavonoids in Biology & Medicine. 1989 Nov 13–17; Singapore, China; 1989.

Ernst E, März RW, Seider C. Acute bronchitis—benefits of Sinupret® [in German]. Fortschritte der Medizin 1997;115(11):52–3.

ESCOP. See: European Scientific Cooperative on Phytotherapy.

European Scientific Cooperative on Phytotherapy (ESCOP). Valeriana radix. Monographs on the medicinal uses of plants. Exeter: ESCOP;1997.

FAC. See: Food Advisory Committee.

Fallarino M. Tibetan medical paintings: illustrations to the blue beryl treatis of sangye gyamtso (1653–1705). HerbalGram 1994;31:38–44.

FDA. See: Food and Drug Administration.

Feine-Haake G. A new therapy for venous diseases with 3,3’ 4,4’ 5,7-hexadihydro- flavan. Allgemeinmedizin 1975;51:839.

Fishman RHB. Antioxidants and phytotherapy. Lancet 1994 Nov 12;344:1356.

Fitzpatrick DF, Bing B, Rohdewald P. Endothelium-dependent vascular effects of Pycnogenol. J Cardiovasc Pharmacol 1998;32(4):509–15.

Food Advisory Committee (FAC). French maritime pine bark extract. Food for Thought 1999;Autumn:2–3.

Food and Drug Administration (FDA). 65 FR 1000–1050. Jan 6, 2000. Regulations on statements made for dietary supplements concerning the effect of the product on the structure or function of the body. [Docket No. 98N–0044] 21 CFR Part 101–93..

Forth H, Beuscher N. Influence of Esberitox® on the frequency of the common cold [in German]. Zeutschrift für Allgemeinmedizin 1981;57:2272–5.

Foster S. American Herbal Products Association: Herbs of Commerce. Austin (TX): American Herbal Products Association; 1992.

Freise J, Köhler S. Peppermint oil-caraway oil fixed combination in non-ulcer dyspepsia—comparison of the effects of enteric preparations [in German]. Pharmazie 1999;54(3):210–5.

Fussel A, Wolf A, Brattström A. Effect of a fixed valerian-hop extract combination (Ze 9109) on sleep polygraphy in patients with non-organic insomnia: a pilot study. Eur J Med Res 2000;5:385–90.

Gábor M, Engi E, Sonkodi S. The influence of water soluble flavonoid derivates on capillary resistance in hypertonic rats [in German]. Phlebologie 1993;(22):178–82.

Gerhard U, Linnenbrink N, Georghiadou C, Hobi V. Vigilance-decreasing effects of 2 plant-derived sedatives. Schweiz Rundsch Med Prax 1996;85(15):473–81.

Gieldanowski J. Padma 28® modifies immunological functions in experimental atherosclerosis in rabbits. Arch Immunol Ther Exp 1992;40:291–5.

Ginsburg I, Sadovnik M, Sallon S, et al. PADMA-28, a traditional Tibetan herbal preparation inhibits the respiratory burst in human neutrophils, the killing of epithelial cells by mixtures of oxidants and pro-inflammatory agonists and peroxidation of lipids. Inflammopharmacology 1999;7(1):47–62.

Gulati OP. Pycnogenol® in venous disorders [review]. Euro Bull Drug Res 1999;7(2):8–13.

Guochang Z. Ultraviolet radiation-induced oxidative stress in cultured human skin fibroblasts and antioxidant protection [dissertation]. In: Biological Research Reports from the University of Jyväskylä 33:1–86. Jyväskylä, Finland: University of Jyväskylä; 1993.

Hahn S, Hubner-Steiner U. Behandlung schmerzhafter rheumatischer erkrankungen mit Phytodolar N im verglerch zur placebo- und Ammuno-Behandhung. Rheuma Schmerz und Entznndung 1988;8:55–8.

Hawel R. Phytodolor® vs. Diclofenac bei rheumatischen erkrankungen. Steigerwald, Gmbh. Interner Forschungsbericht 1991.

Health Canada. Drug Product Database (DPD). Ottawa, Ontario: Health Canada Therapeutic Products Programme (TPP); 2001.

Health Protection Branch. Pycnogenol®. In: HPB Status Manual. Ottawa, Ontario: Health Protection Branch; 1993. p. 158.

Hendriks H, Bos R, Allersma D, Malingre T, Koster A. Pharmacological screening of valerenal and some other components of essential oil of Valeriana officinalis. Planta Med 1981;42:62–8.

Henneicke-von Zepelin H, Hentschel C, Schnitker J, Kohnen R, Kohler G, Wustenberg P. Efficacy and safety of a fixed combination phytomedicine in the treatment of the common cold (acute viral respiratory tract infection): results of a randomised, double blind, placebo controlled, multicentre study. Curr Med Res Opin 1999;15(3):214–27.

Herzog U, Fitzek J, Franek H. Phytodolor® N versus Diclofenac Wirksamkeit und VertSglichkeit. Steigerwald, Gmbh. Interner Forschungsbericht 1991.

Hiller K. Neuropharmacological studies on ethanol extracts of Valeriana officinalis L: behavioral and anticonvulsant properties. Phytother Res 1996;10:145–51.

Hosseini S, Lee J, Sepulveda RT, Rohdewald P, Watson RR. A randomized, double-blind, placebo-controlled, prospective, 16 week crossover study to determine the role of Pycnogenol® in modifying blood pressure in mildly hypertensive patients. Nutr Res 2001a;21:12(9):1251-1260.

Hosseini S, Pishnamazi S, Sadrzadeh SMH, Farid F, Farid R, Watson RR. Pycnogenol® in the management of asthma. Medicinal Food 2001b;4(4):201–8.

HPB. See: Health Protection Branch.

Hsu, H-Y, et al. Oriential Materia Medica: A Concise Guide. Long Beach, Calif: Oriental Healing Arts Institute, 1986. http://www.tsumura.co.jp/english/kthp/4-2-01.htm#6

Huber B. Therapy of degenerative rheumatic diseases. Need for additional analgesic medication with Phytodolor N [in German]. Fortschr Med 1991;109;11:248–50.

Huynh HT, Teel RW. Selective induction of apoptosis in human mammary cancer cells (MCF-7) by Pycnogenol. Anticancer Res 2000;20(4):2417–20.

Igarashi T, Gonoi T, Hanada M, Sato H, et al. Study on effect of Hochu-ekki-to® (TJ-41) on anorexia, fatigue and malaise, and Kampo diagnosis of Hochu-ekki-to®. Therapeutic Research 1995;15(11):4526–30.

Ismail CH, Queißer-Luft A, Becker MKF, Marz RW. Sinupret® in pregnancy, submitted to Archives of Gynecology and Obstetrics, 2001.

Israelsen LD, Blumenthal M. FDA issues final rules for structure/function claims for dietary supplements under DSHEA. HerbalGram 2000;48:32–8.

Jankowski S, Jankowski A, Zielinska S, Walczuk M, Brzosko WJ. Influence of Padma 28® on the spontaneous bactericidal activity of blood serum in children suffering from recurrent infections of the respiratory tract. Phytother Res 1991;5:120–3.

Japan Kampo-Medicine Manufacturers Association. 1998 Sales Volume of Top Ten Kampo Formulations. Kampo Today 2001;4(2):2.

Kammerer E, Brattst öm A, Herberg K-W. Effects of a hop-valerian combination on fitness and driving safety. Der Bay Int 1996;16(3):32–6.

Kapoor LD. Handbook of Ayurvedic Medicinal Plants. Boca Raton (FL): CRC Press; 1990.

Karibe H. The effect of Japanese herbal medicine on MRSA carriers in neurosurgery. Neurol Surg 1997;25(10):893–7.

Khajuria A, Zutshi U, Bedi KL. Permeability characteristics of piperine on oral absorption — an active alkaloid from peppers and a bioavailability enhancer. Indian J Exp Biol 1998;36(1):46–50.

Khangkar LD. Lectures on Tibetan Medicine, 1986 Library of Tibetan Works and Archives, Dharamsala.

Kobayashi MS, Han D, Packer L. Antioxidants and herbal extracts protect HT4- neuronal cells against glutamate-induced cytoxicity. Free Rad Res 2000;32(2):115–24.

Kohama T, Suzuki N. The treatment of gynecological disorders with Pycnogenol®. Euro Bull Drug Res 1999;7(9):30–2.

Kraus P, Schwender W. Randomized, open comparative study with Sinupret® sugar-coated tablets vs. Gelomyrtol® F. conducted at the German Army Hospital in Amberg [abstract]. 4th National and 1st International Congress on Phytotherapy; 1992 Sep 10-13; Munich, Germany.

Kuratsune H, et al. Effect of Kampo medicine, “Hochu-ekki-to®”, on chronic fatigue syndrome. Clinic and Res 1997;74:1837–45.

Lad V, Frawley D. The Yoga of Herbs: An Ayurvedic Guide to Herbal Medicine. Santa Fe (NM): Lotus Press; 1986.

Lataster MJ, Brattström A. The treatment of patients with sleep disorders: efficacy of tolerance of valerian-hop tablets. Notabene Medici 1996;4:182–5.

Leatherwood PD, Chauffard F, Heck E, Munoz-Box R. Aqueous extract of valerian root (Valerianan officinalis L.) improves sleep quality in man. Pharmacol Biochem Behav 1982;17(1):65–71.

Leuschner J, Mueller J, Rudmann M. Characterization of the central nervous depressant activity of a commercially available valerian root extract [in German]. Arzneimittelfforschung 1993;43:638–41.

Liu FJ, Zhang YX, Lau BHS. Pycnogenol® enhances immune and haemopoietic functions in senescence-accelerated mice. Cell Mol Life Sci 1998;54(10):1168–72.

Liu FJ, Zhang Y, Lau BHS. Pycnogenol® improves learning impairment and memory deficit in senescense-accelerated mice. J Anti-Aging Med 1999;2:349–55.

Madisch A, Heydenreich CJ, Wieland V, et al. Treatment of functional dyspepsia with a fixed peppermint oil and caraway oil combination preparation as compared to cisapride. A multicenter, reference-controlled double-blind equivalence study. Arzen 1999;49(11):925–32.

Magnard G, Franck JP, Dorne PA. Use of tetrahydroxy flavan-diol in ophthalmology especially in chronic retinopathy (40 cases) [in French]. Lyon Medical 1970;223(4):259–63.

Marks L, Hess D, Dorey F, et al. Tissue effects of saw palmetto and finasteride: use of biopsy cores for in situ quantification of prostatic androgens. Urol 2001;57(3):999–1005.

Marks L, Partin A, Epstein J, et al. Effects of a saw palmetto herbal blend in men with symptomatic benign prostatic hyperplasia. Jour of Urol 2000 May;163:1451–1456.

Matzner Y, Sallon S. The effect of Padma 28®, a traditional Tibetan herbal preparation, on human neutrophil function. J Clin. Lab Immunol 1995;46:13–23.

McGuffin M, Hobbs C, Upton R, Goldberg A. American Herbal Product Association’s Botanical Safety Handbook. Boca Raton (FL): CRC Press;1997.

Medical Products Agency (MPA). Naturläkemedel (Authorised Natural Remedies). Uppsala, Sweden: Medical Products Agency; 2001.

Mehlsen J, Drabaek H, Peterson JR, Winther K. Der effekt einer tibetischen krautermischung (Padma 28®) auf die gehstrecke bei stabiler claudicatio intermittens. Forsc Komplementarmed 1995;2:240–5. (See also: Angiology 1993;44:863–7.)

Melchart D, Linde K, Worku F, Bauer R, Wagner H. Immunomodulation with Echinacea—a systematic review of controlled clinical trials. Phytomed 1994;1:245–254.

Mendal JN, Roy BK. Hepatitis, chronic active hepatitis and cirrhosis of the liver. Probe 1983;4:217.

Metzker H, Kieser M, Hölscher U. Efficacy of a combined Sabal-Urtica preparation in the treatment of benign prostatic hyperplasia (BPH): A double-blind, placebo-controlled, long-term study. Urologe 1996;36:292–300.

Micklefield GH, Greving I, May B. Effects of peppermint oil and caraway oil on gastroduodenal motility. Phytother Res 2000;14:20–3.

Miller L. Herbal medicinals: selected clinical considerations focusing on known or potential drug-herb interactions. Arch Intern Med 1998;158:2200–11.

Moerman D. Native American Ethnobotany. Portland (OR): Timber Press; 1998.

Moeslinger T, Friedl R, Volf I, Brunner M, Koller E, Spieckermann PG. Inhibition of inducible nitric oxide synthesis by the herbal preparation Padma 28® in macrophage cell line. Can J Physiol 2000;78:861–6.

Morazzoni P, Bombardelli E. Valeriana officinalis: traditional use and recent evaluation of activity. Fitoterapia 1995;66:99–112.

Mori K, Saito Y, Tominaga K. Utility of Hochu-ekki-to® in general malaise accompanying lung cancer chemotherapy. Biotherapy 1992;6(4):624–7.

MPA. See: Medical Products Agency.

Nefyodov LI, Doroshenko YM, Karavay NL, Brzosko WJ. Effect of Padma 28® on impaired amino acid metabolism induced by liver inflammatory pathology. Herba Polonica 2000;XLVI(4):340–5.

Nelson AB, Lau BHS, Ide N, Rong Y. Pycnogenol® inhibits macrophage oxidative burst, lipoprotein oxidation and hydroxyl radical-induced DNA damage. Drug Development and Industrial Pharmacy 1998;24(2):139–44.

Neubauer N, März RW. Placebo-controlled, randomized double-blind clinical trial with Sinupret® sugar-coated tablets on the basis of a therapy with antibiotics and decongestant nasal drops in acute sinusitis. Phytomedicine 1994;1(3):177–81.

Niwa M, et al. Effect of Hochu-ekki-to® (TJ-41) on immune function. Progress in Medicine 1996;16:1506–8.

ORG-MARG Private Limited. Syndicated retail audit conducted on the Indian Pharma industry. Operations Research Group (ORG) and Marketing & Research Group (MARG) (ORG-MARG Private Limited); 2001,

Ozaki, Y, Ma, JP. Inhibitory effects of tetramethylpyrazine and ferulic acid on spontaneous movement of rat uterus in situ. Chem Pharm Bull (Tokyo) 1990;38(6):1620–3.

Packer L, Rimbach G, Virgili F. Antioxidant activity and biologic properties of a procyanidin-rich extract from pine (Pinus maritima) bark, Pycnogenol. Free Rad Biol & Med 1999;27(5–6):704–24.

Padma Advertisement. Alternative Therapies 2000 Sept;6(5):45.

Patney NL, Kumar A. Preliminary Report on the Role of Liv. 52® – An Ayurvedic drug in Serum B hepatitis (Australian Antigen Positive) cases. Probe 1978;2:132.

Petrassi C, Mastromarino A, Spartera C. Pycnogenol in chronic venous insufficiency. Phytomedicine 2000;7(5):383–8.

Pinnow R, Egentenmaier J. Controlled clinical trials in achute (tracheo-) bronchitis: Sinupret® sugar-coated tablets vs. Mucret, Sinupret® drops vs. Mucosolvan drops in uncomplicated acute (tracheo-) bronchitis. Abstract presented at the 4th National and 1st International Congress on Phytomedicine, Munich, 1992.

Pütter M, Grotemeyer KH, Würthwein G, Araghi-Niknam M, Watson RR, Hosseini S, et al. Inhibition of smoking-induced platelet aggregation by aspirin and pycnogenol. Thrombosis Res 1999;95(4):155–61.

Queißer-Luft A., Ismail Ch. Safety of an herbal combination preparation in pregnancy—an example for using active detection systems for malformations, abstracts 3rd International Congress on Phytomedicine. 2000;7(2):12.

Reitz, HD. Immunomodulation with phytotherapeutic agents: a scientific study on the example of Esberitox® [in German]. Notebene medici 1990;20:362–6.

Riechstein A, Mann W. Treatment of chronic rhino-sinusitis with Sinupret®: a double-blind prospective clinical trial. Schweizerische Zeitschrift fur Ganzheits Medizin 1999;11(6):280–3.

Rihn B, Saliou C, Bottin MC, Keith G, Packer L. From ancient remedies to modern therapeutics: pine bark uses in skin disorders revisited. Phytotherapy Res 2001;15(1):76–8.

Rohdewald P. Pycnogenol® In: Rice-Evans CA, Packer L, editors. Flavonoids in Health and Disease. New York (NY): Marcel Dekker, Inc.; 1998. p. 405–19.

Rohdewald P. A review of the French maritime pine bark extract (Pycnogenol), a herbal medication with a diverse clinical pharmacology. Int J Clin Pharm Ther 2002;40(4):158–68.

Roseff SJ, Gulati R. Improvement of sperm quality by Pycnogenol®. Euro Bull Drug Res 1999;7(2):33–6.

Ruppanner H, Schaefer U, editors. Kräuterpfarrer Künzle AG Pygenol. In: Codex 2000/01 — Die Schweizer Arzneimittel in einem Griff. Basel, Switzerland: Documed AG; 2000. p. 459.

Rüve HJ. Identifizierung und Quantifizierung phenolischer Inhaltsstoffe sowi pharmakologisch-biochemische Untersuchungen eines Extraktes aus der Rind der Meereskiefer Pinus pinaster Ait. [doctoral thesis]. Münster, Germany:1996.

Sakamoto T, Mitani Y, Nakajima K. Psychotropic effects of Japanese valerian root extract. Chem & Pharm Bull 1992;40:758–61.

Saliou C, Rimbach G, Moini H, McLaughlin L, Hosseini S, Lee J, et al. Solar ultraviolet-induced erythema in human skin and nuclear factor-kappa-B-dependent gene expression in keratinocytes are modulated by a French maritime pine bark extract. Free Radic Biol Med 2001;30(2):154–60.

Sallon S, Beer G, Rosenfeld J, Anner H, Volcoff D, Ginsburg G, Paltiel O, Berlatzky Y. The efficacy of Padma 28®, a herbal preparation, in the treatment of intermittent claudication: a controlled double-blind pilot study with objective assessment of chronic occlusive arterial disease patients. J Vasc Invest 1998;4(3):129–36.

Sama SK, Krishnamurthy L, Ramachandran K, Krishnan L. Efficacy of Liv.52 in acute viral hepatitis: a double-blind study. Indian Journal of Medical Research 1976;5:738.

Samochowiec J, Palacz A, Bobnis W, Lisiecka B. Oscillating potentials of the electroretinogram in the evaluation of the effects of Padma 28® on lipid metabolism and vascular changes in humans. Phytotherapy Research 1992;6:200–4.

Samochowiec L, Wojcicki J. Effect of Padma 28® on lipid endoperoxides formation. Herba Polonica 1987;33(3):219–22.

Samochowiec L, Wojcicki J, Kosmider K, et al. Clinical test of the effectiveness of Padma 28® in the treatment of patients with chronic arterial occlusion. Herba Polonica 1987;33(1):29–41.

Saur E, Rotival N, Lambrot C, Trichet P. Maritime pine dieback on the West Coast of France: Growth response to sodium chloride of 3 geographic races in various edaphic conditions. Ann des Sci Forestieres (Paris) 1993;50(4):389–99.

Saxena S, Garg AK, Jain A. A study of Liv.52 therapy in Infective hepatitis in children. Current Medical Practice 1980;5:194.

Schilcher H. Personal communication to M. Blumenthal, Dec. 30, 1997.

Schilcher H. Phytotherapy in Pediatrics: Handbook for Physicians and Pharmacists, 2nd ed. Stuttgart: Medpharm Scientific Publishers;1997.

Schmidtke I, Schoop W. Hydrostatic oedema and the effect of medicinal products [in German]. Swiss Med 1984;6(4a):67–9.

Schmidtke I, Schoop W. Pycnogenol—stasis oedma and its medical treatment [in German]. Z Ganzheits Med 1995;3:114–5.

Schmitz M, Jackel M. [Comparative study for assessing quality of life of patients with exogenous sleep disorders (temporary sleep onset and sleep interruption disorders) treated with a hops-valerian preparation and a benzodiazepine drug]. Wien Med Wochenschr 1998;148(13):291–8.

Schneider HJ, Honold E, Masuhr Th. Treatment of benign prostatic hyperplasia: Results of a surveillance study in the practices of urological specialists using a combined plant-based preparation (Sabal extract WS 1473 and Urtica extract WS 1031). Fortschr Med 1995;113(3):37–40.

Schrader R, Nachbur M, Mahler F. Die Wirkung des tibetischen krauterpraparates Padma 28® auf die claudicatio intermittens. Schweiz Med Wschr 1985;115.

Schreckenberger F. Die behandlung von epicondylitiden mit Phytodolor®. Österreichische Zeitschrift fur Allgemeinmedizin 1988;42:1638–44.

Singh KK, Singh YK, Sinha SK, Sharma V, Mishra BN. Observatory treatment of infectious hepatitis with Ayurvedic drug - Liv.52. Ind Med J 1977;5:69.

Sirnelli-Walter L, Wiel-Masson D. Therapeutic evaluation of leucocyanidol (FLAVAN) in venous insufficiency in medical gynaecological consultation [in French]. Artéres et Veines 1988;7.

Smulski HS, Wójcicki J. Placebo-controlled, double-blind trial to determine the efficacy of the Tibetan plant preparation Padma 28® for intermittent claudication. Alternative Therapies 1995 July;1(3). Reprinted from: Smulski HS, Wsojcici J. Plazebokontrollierte doppelblindstudie zur wirkung des tibetanischen krauterpraparates Padma 28® auf die claudicatio intermittens. Forsch Komplementarmed 1994;1.

Sökeland J, Albrecht J. A combination of Sabal and Urtica extracts vs. Finasteride in BPH (Stage I and II acc. To Alken): a comparison of therapeutic efficacy in a one-year double blind study. Urologe 1997;36:327–33.

Spadea L, Balestrazzi E. Treatment of vascular retinopathies with Pycnogenol®. Phytotherapy Res 2001;15(3):219–23.

Stefanescu M, Matache C, Onu A, Tanaseanu S, Dragomir C, Constantinescu I, et al. Pycnogenol efficacy in the treatment of systemic lupus erythematosus patients. Phytother Res 2001;15(8):698–704.

Suter M, Richter C. Anti- and pro-oxidative properties of PADMA 28®, a Tibetan herbal formulation. Redox Report 2000;5(1):17–22.

United States Congress (USC). Dietary Supplement Health and Education Act of 1994, Pub. L. No. 103–417 (1994).

USC. See: United States Congress.

Vonderheid-Guth B, Todorova A, Brattstöm A, Dimpfel W. Pharmacodynamic effects of valerian and hops extract combination (Ze 9109) on the quantitative-topographical EEG in healthy volunteers. Eur J Med Res 2000;5:139–44.

Vorberg G. For colds, stimulate the nonspecific immune system. Arztl Prax 1984;35(6):97–8.

Wang S, Duanjun T, Yusheng Z, Guankai G, Xue G, Hu L. The effect of Pycnogenol® on the microcirculation, platelet function and ischaemic myocardium in patients with coronary artery diseases. Eur Bull Drug Res 1999;7:19–25.

Watson RR. Reduction of cardiovascular disease risk factors by French maritime pine bark extracts. CVR&R 1999 June;326–9.

Wei ZH, Peng QL, Lau BHS. Pycnogenol enhances endothelial cell antioxidant defence. Redox Report 1997;3(4):219– 24.

WHO. See: World Health Organization.

Winther K, Kharazmi A, Himmelstrup H, Drabaek H, Mehlson J. Padma 28®, a botanical compound, decreased the oxidative burst response of monocytes and improves fibrinolysis in patients with stable intermittent claudication. Fibrinolysis 1994;8(Suppl 2):47–9.

Wójcicki J, Gonet B, Samochowiec L, Gnacin’ska K, Juz’wiak S. Effect of Padma 28® on ascorbate system in rats receiving a high fat diet. Phytother Res 1989b;3:54–6.

Wójcicki J, Samochowiec L.Controlled double-blind study of Padma 28® in Angina Pectoris. Herba Pol 1986;32:107–14.

Wójcicki J, Samochowiec L, Ceglecka M, Juzyszyn Z, Tustanowski S, Kadtubowska D, Juz’wiak S. Effect of Padma 28® on experimental hyperlipidaemia and atherosclerosis induced by high-fat diet in rabbits. Phytother Res 1988;2:119–23.

Wójcicki J, Samochowiec L, Kadlubowska D. Inhibition of ethanol-induced changes in rats by Padma 28®. Acta Physiol Pol 1989a;40:387–92.

World Health Organization (WHO). WHO Monographs on Selected Medicinal Plants, vol. 1. Geneva: WHO, 1999.