References for Proprietary Products
Alder D [BotanicLab]. Personal communication to M
Blumenthal, Mar. 13, 2002.
Albrecht M, Berger W, Laux P, Schmidt U, Martin C.
Psychopharmaceuticals and traffic safety: The influence of Euvegal® forte
sugar-coated tablets on driving ability and combination effect with alcohol. Z Allg Med 1995;71:1215–25.
Ammer K, Melnizky P. Medicinal baths for treatment of
generalized fibromyalgia [in German]. Forsch
Komplementarmed 1999;6:80–5.
Anonymous. Sinupret® for sinusitis and inflammation of the
respiratory tract. (manufacturer’s booklet). Neumarkt, Germany: Bionorica
Arzneimittel GmbH.
Anonymous. Various studies show Hochu-ekki-to® is effective
in aiding recovery. Kampo Today
2001;4(2):1–3,6.
Arcangeli R. Pycnogenol in chronic venous insufficiency. Fitoterapia 2000;71(3):236–44.
Atal CK, Dubey RK, Singh J. Biochemical basis of enhanced
drug bioavailability by piperine: evidence that piperine is a potent inhibitor
of drug metabolism. J Pharmacol Exp Ther
1985;232(1):258–62.
Atal CK, Zutshi U, Rao PG. Scientific evidence on the role
of Ayurvedic herbals on bioavailability of drugs. J Ethnopharmacol 1981;4(2):229–32.
Badmaev VV, Majeed M, Prakash L. Piperine derived from black
pepper increases the plasma levels of coenzyme q10 following oral
supplementation. J Nutr Biochem
2000;11(2):109–13.
Bahrman N, Zivy M, Damerval C, Baradat P. Organisation of
the variability of abundant proteins in seven geographical origins of maritime
pine (Pinus pinaster Ait.). Theoretical & Applied Genetics 1994;88(3–4):407–11.
Bano G, Raina RK, Zutshi U, Bedi KL, Johri RK, Sharma SC.
Effect of piperine on bioavailability and pharmacokinetics of propranolol and
theophylline in healthy volunteers. Eur J
Clin Pharmacol 1991;41(6):615–7.
Baumann D, Focke G, Kornosoff G. Phytodolor® bei patienten
mit aktivierter gonarthrosse, koxanthrose bzw. Schulter-Arm-Syndrom.
Multizentrische randomisierte doppelblindstudie versus Diclofenac-Natrium.
Steigerwald, Gmbh. Interner Forschungsbericht 1989.
Bensoussan A, Talley NJ, Hing M, et al. Treatment of
irritable bowel syndrome with Chinese herbal medicine. JAMA 1998;280(18):1585–9.
Bernhardt M, Keimel A, Belucci G, Spasojevic P.
Doppelblinde, randomisierte vergleich von Phytodolor® N und placebo sowie
offener vergleich zu felden 20 tabs bei stationaren kurpatienten mit
arthrotischen GelenkverSnderungen [in German]. Unpublished trial, Steigerwald,
Germany, 1990.
Bernhardt M, Keimel A, Belucci G, Spasojevic P.
Doppelblinde, randomisierte vergleichstudie von Phytodol® N und placebo sowie
offener vergleich zu felden 20 tabs bei stationaren kurpatienten mit
arthrotischen GelenkverSnderungen [in German]. Unpublished trial, Steigerwald,
Germany, 1991.
Blazsó G, Gábor M, Rohdewald P. Anti-inflammatory activities
of procyanidin-containing extracts from Pinus
pinaster Ait. after oral and cutaneous application. Pharmazie 1997;52(5):380–2.
Blazsó G, Gábor M, Sibbel R, Rohdewald P. Anti-inflammatory
and superoxide radical scavenging activities of procyanidin-containing extracts
from the bark of Pinus pinaster Sol.
and its fractions. Pharm Pharmacol Lett 1994;3:217–20.
Blazsó G, Gaspar R, Gábor M, Rüve H-J, Rohdewald P. ACE
inhibition and hypotensive effect of procyanidins containing extract from the
bark of Pinus pinaster Sol. Pharm Pharmacol Lett 1996;6(1):8–11.
Blazsó G, Rohdewald P, Sibbel R, Gábor M. Anti-inflammatory
activities of procyanidin-containing extracts from Pinus pinaster Sol. In: Antus S, Gábor M, Vetschera K, editors. Proceedings of the International
Bioflavonoid Symposium; 1995 July 16–19; Vienna, Austria; 1995. p. 231–8.
Blumenthal M. Herb sales down 15% in mainstream market. HerbalGram 2001;51:69.
Blumenthal M, Busse WR, Goldberg A, Gruenwald J, Hall T,
Riggins CW, Rister
RS editors. Klein S, Rister RS (trans.). The
Complete German Commission E
Monographs—Therapeutic Guide to Herbal Medicines. Austin (TX): American
Botanical Council; Boston (MA): Integrative Medicine Communication; 1998.
Bos R, Hendriks H, Scheffer J, Woerdenbag H. Cytotoxic
potential of valerian constituents and valerian tinctures. Phytomedicine 1998;5:219–25.
Braeckow R, Eickstedt K, Kuhne U. Effects of chlorpromazine
and valtratum on ethanol anesthesia and ethanol blood level. Arzneimittelforschung 1972;22:1977–80.
Braum D, März R. Randomised, open comparative study of
sinupret versus n-acetylcysteine in cases of sinusitis. Bundeswehrkrankenhaus
(military hospital), Giessen. 1990.
Brinker F. Herb
Contraindications and Drug Interactions, 3d ed. Sandy (OR): Eclectic
Institute;2001.
Buz’Zard AR, Peng Q, Lau BH. Kyolic® and Pycnogenol®
increase human growth hormone secretion in genetically-engineered
keratinocytes. Growth Horm & IGF Res
2002;12(1):34–40.
California State Dept. Human Services, Food and Drug Branch.
State health director warns consumers about prescription drugs in herbal
products. Feb 7, 2002. Available from URL: http://www.dhs.ca.gov.
Chan T. An assessment of the delayed effects associated with
valerian overdose [letter]. Int J Clin
Pharmacol Ther 1998;36:569.
Chan T, Tang C, Critchley J. Poisoning due to an
over-the-counter hypnotic sleep-Qik (hyoscine, cyproheptadine, valerian). Postgrad Med J 1995;71:227–8.
Chandler RF, Freeman L, Hooper SN. Herbal remedies of the
maritime Indians. J Ethnopharmacology
1979;1(1):49–68.
Chauhan BL, Kulkarni RD. Liv.52 in alcoholic liver diseases:
a profile of an herbal remedy. Eur J Clin
Pharmacol 1991;40(2):189–91.
Cheshier JE, Ardestani-Kaboudanian S, Liang B, Araghiniknam
M, Chung S, Lane L, et al. Immuno-modulation by Pycnogenol in
retrovirus-infected or ethanol-fed mice. Life
Sci 1996;58(5):87–96.
Crates E. Pycnogenol– barking up the right tree. Funct Foods & Nutraceuticals
2000;3(13):16–7.
Dharmananda S. The nature of ginseng: traditional use,
modern research, and the question of dosage.
HerbalGram 2002;54:34–51.
Dietary Supplement Health and Education Act of 1994 (DSHEA),
Public Law 103-417, 21 USC § 3419.
Doucet M, Durand-Cagniart MO, Tanger-Rubin M. The value of
FLAVAN for functional symptoms and the prevention of venous insufficiency. Act Méd Int 1987;4(59):2–4.
Drabaek H, Mehlsen J, Himmelstrup H, Winther K. A botanical
compound, Padma® 28, increases walking distance in stable intermittent
claudication. Angiology
1993;44(11):863–7.
Dressing H, Köhler S, Müller WE. Improvement of sleep
quality with a high-dose valerian/lemon balm preparation: a placebo-controlled
double-blind study. Psychopharma
1996;3:123–30.
Dressing H, Riemann D, Löw H, et al. Insomnia: are
valerian/balm combinations of equal value to bezodiazepine? Therapiewoche, 42 1992 Mar;12:726–736.
DSHEA. See: Dietary Supplement Health and Education Act of
1994.
Dutkeiwicz T, Samochowiec L, Wójcicki J. Padma 28® modifies
immunological functions in experimental atherosclerosis in rabbits. Archivum Immunologiae et Therapiae
Experimentalis 1992;40:291–5.
Egetenmaier J, März R. Double-blind study of Sinupret drops
versus ambroxol drops in acute uncomplicated (tracheo-) bronchitis. 1991.
Elstner E, Kleber E. Radical scavenger properties of
leucocyanidine. Proceedings of the 3rd International Symposium on Flavonoids in
Biology & Medicine. 1989 Nov 13–17; Singapore, China; 1989.
Ernst E, März RW, Seider C. Acute bronchitis—benefits of
Sinupret® [in German]. Fortschritte der
Medizin 1997;115(11):52–3.
ESCOP. See: European Scientific Cooperative on Phytotherapy.
European Scientific Cooperative on Phytotherapy (ESCOP). Valeriana radix. Monographs on the medicinal
uses of plants. Exeter: ESCOP;1997.
FAC. See: Food Advisory Committee.
Fallarino M. Tibetan medical paintings: illustrations to the
blue beryl treatis of sangye gyamtso (1653–1705). HerbalGram 1994;31:38–44.
FDA. See: Food and Drug Administration.
Feine-Haake G. A new therapy for venous diseases with 3,3’
4,4’ 5,7-hexadihydro- flavan. Allgemeinmedizin
1975;51:839.
Fishman RHB. Antioxidants and phytotherapy. Lancet 1994 Nov 12;344:1356.
Fitzpatrick DF, Bing B, Rohdewald P. Endothelium-dependent
vascular effects of Pycnogenol. J
Cardiovasc Pharmacol 1998;32(4):509–15.
Food Advisory Committee (FAC). French maritime pine bark
extract. Food for Thought 1999;Autumn:2–3.
Food and Drug Administration (FDA). 65 FR 1000–1050. Jan 6,
2000. Regulations on statements made for dietary supplements concerning the
effect of the product on the structure or function of the body. [Docket No.
98N–0044] 21 CFR Part 101–93..
Forth H, Beuscher N. Influence of Esberitox® on the
frequency of the common cold [in German]. Zeutschrift
für Allgemeinmedizin 1981;57:2272–5.
Foster S. American
Herbal Products Association: Herbs of Commerce. Austin (TX): American
Herbal Products Association; 1992.
Freise J, Köhler S. Peppermint oil-caraway oil fixed
combination in non-ulcer dyspepsia—comparison of the effects of enteric
preparations [in German]. Pharmazie
1999;54(3):210–5.
Fussel A, Wolf A, Brattström A. Effect of a fixed
valerian-hop extract combination (Ze 9109) on sleep polygraphy in patients with
non-organic insomnia: a pilot study. Eur
J Med Res 2000;5:385–90.
Gábor M, Engi E, Sonkodi S. The influence of water soluble
flavonoid derivates on capillary resistance in hypertonic rats [in German]. Phlebologie 1993;(22):178–82.
Gerhard U, Linnenbrink N, Georghiadou C, Hobi V.
Vigilance-decreasing effects of 2 plant-derived sedatives. Schweiz Rundsch Med Prax 1996;85(15):473–81.
Gieldanowski J. Padma 28® modifies immunological functions
in experimental atherosclerosis in rabbits. Arch
Immunol Ther Exp 1992;40:291–5.
Ginsburg I, Sadovnik M, Sallon S, et al. PADMA-28, a
traditional Tibetan herbal preparation inhibits the respiratory burst in human
neutrophils, the killing of epithelial cells by mixtures of oxidants and
pro-inflammatory agonists and peroxidation of lipids. Inflammopharmacology 1999;7(1):47–62.
Gulati OP. Pycnogenol® in venous disorders [review]. Euro Bull Drug Res 1999;7(2):8–13.
Guochang Z. Ultraviolet radiation-induced oxidative stress
in cultured human skin fibroblasts and antioxidant protection [dissertation]. In:
Biological Research Reports from the University of Jyväskylä 33:1–86. Jyväskylä,
Finland: University of Jyväskylä; 1993.
Hahn S, Hubner-Steiner U. Behandlung schmerzhafter
rheumatischer erkrankungen mit Phytodolar N im verglerch zur placebo- und
Ammuno-Behandhung. Rheuma Schmerz und
Entznndung 1988;8:55–8.
Hawel R. Phytodolor® vs. Diclofenac bei rheumatischen
erkrankungen. Steigerwald, Gmbh. Interner
Forschungsbericht 1991.
Health Canada. Drug
Product Database (DPD). Ottawa, Ontario: Health Canada Therapeutic Products
Programme (TPP); 2001.
Health Protection Branch. Pycnogenol®. In: HPB Status Manual. Ottawa, Ontario:
Health Protection Branch; 1993. p. 158.
Hendriks H, Bos R, Allersma D, Malingre T, Koster A.
Pharmacological screening of valerenal and some other components of essential
oil of Valeriana officinalis. Planta Med 1981;42:62–8.
Henneicke-von Zepelin H, Hentschel C, Schnitker J, Kohnen R,
Kohler G, Wustenberg P. Efficacy and safety of a fixed combination
phytomedicine in the treatment of the common cold (acute viral respiratory
tract infection): results of a randomised, double blind, placebo controlled,
multicentre study. Curr Med Res Opin
1999;15(3):214–27.
Herzog U, Fitzek J, Franek H. Phytodolor® N versus
Diclofenac Wirksamkeit und VertSglichkeit. Steigerwald, Gmbh. Interner Forschungsbericht 1991.
Hiller K. Neuropharmacological studies on ethanol extracts
of Valeriana officinalis L:
behavioral and anticonvulsant properties. Phytother
Res 1996;10:145–51.
Hosseini S, Lee J, Sepulveda RT, Rohdewald P, Watson RR. A
randomized, double-blind, placebo-controlled, prospective, 16 week crossover
study to determine the role of Pycnogenol® in modifying blood pressure in
mildly hypertensive patients. Nutr Res
2001a;21:12(9):1251-1260.
Hosseini S, Pishnamazi S, Sadrzadeh SMH, Farid F, Farid R,
Watson RR. Pycnogenol® in the management of asthma. Medicinal Food 2001b;4(4):201–8.
HPB. See: Health Protection Branch.
Hsu, H-Y, et al. Oriential Materia Medica: A Concise Guide.
Long Beach, Calif: Oriental Healing Arts Institute, 1986.
http://www.tsumura.co.jp/english/kthp/4-2-01.htm#6
Huber B. Therapy of degenerative rheumatic diseases. Need
for additional analgesic medication with Phytodolor N [in German]. Fortschr Med 1991;109;11:248–50.
Huynh HT, Teel RW. Selective induction of apoptosis in human
mammary cancer cells (MCF-7) by Pycnogenol. Anticancer
Res 2000;20(4):2417–20.
Igarashi T, Gonoi T, Hanada M, Sato H, et al. Study on effect
of Hochu-ekki-to® (TJ-41) on anorexia, fatigue and malaise, and Kampo diagnosis
of Hochu-ekki-to®. Therapeutic Research
1995;15(11):4526–30.
Ismail CH, Queißer-Luft A, Becker MKF, Marz RW. Sinupret® in
pregnancy, submitted to Archives of
Gynecology and Obstetrics, 2001.
Israelsen LD, Blumenthal M. FDA issues final rules for
structure/function claims for dietary supplements under DSHEA. HerbalGram 2000;48:32–8.
Jankowski S, Jankowski A, Zielinska S, Walczuk M, Brzosko
WJ. Influence of Padma 28® on the spontaneous bactericidal activity of blood
serum in children suffering from recurrent infections of the respiratory tract.
Phytother Res 1991;5:120–3.
Japan Kampo-Medicine Manufacturers Association. 1998 Sales Volume of Top Ten Kampo
Formulations. Kampo Today
2001;4(2):2.
Kammerer E, Brattst öm A, Herberg K-W. Effects of a
hop-valerian combination on fitness and driving safety. Der Bay Int 1996;16(3):32–6.
Kapoor LD. Handbook of
Ayurvedic Medicinal Plants. Boca Raton (FL): CRC Press; 1990.
Karibe H. The effect of Japanese herbal medicine on MRSA
carriers in neurosurgery. Neurol Surg
1997;25(10):893–7.
Khajuria A, Zutshi U, Bedi KL. Permeability characteristics
of piperine on oral absorption — an active alkaloid from peppers and a
bioavailability enhancer. Indian J Exp
Biol 1998;36(1):46–50.
Khangkar LD. Lectures on Tibetan Medicine, 1986 Library of
Tibetan Works and Archives, Dharamsala.
Kobayashi MS, Han D, Packer L. Antioxidants and herbal
extracts protect HT4- neuronal cells against glutamate-induced cytoxicity. Free Rad Res 2000;32(2):115–24.
Kohama T, Suzuki N. The treatment of gynecological disorders
with Pycnogenol®. Euro Bull Drug Res
1999;7(9):30–2.
Kraus P, Schwender W. Randomized, open comparative study
with Sinupret® sugar-coated tablets vs. Gelomyrtol® F. conducted at the German
Army Hospital in Amberg [abstract]. 4th National and 1st International Congress
on Phytotherapy; 1992 Sep 10-13; Munich, Germany.
Kuratsune H, et al. Effect of Kampo medicine,
“Hochu-ekki-to®”, on chronic fatigue syndrome. Clinic and Res 1997;74:1837–45.
Lad V, Frawley D. The
Yoga of Herbs: An Ayurvedic Guide to Herbal Medicine. Santa Fe (NM): Lotus
Press; 1986.
Lataster MJ, Brattström A. The treatment of patients with
sleep disorders: efficacy of tolerance of valerian-hop tablets. Notabene Medici 1996;4:182–5.
Leatherwood PD, Chauffard F, Heck E, Munoz-Box R. Aqueous
extract of valerian root (Valerianan
officinalis L.) improves sleep quality in man. Pharmacol Biochem Behav 1982;17(1):65–71.
Leuschner J, Mueller J, Rudmann M. Characterization of the
central nervous depressant activity of a commercially available valerian root
extract [in German]. Arzneimittelfforschung
1993;43:638–41.
Liu FJ, Zhang YX, Lau BHS. Pycnogenol® enhances immune and
haemopoietic functions in senescence-accelerated mice. Cell Mol Life Sci 1998;54(10):1168–72.
Liu FJ, Zhang Y, Lau BHS. Pycnogenol® improves learning
impairment and memory deficit in senescense-accelerated mice. J Anti-Aging Med 1999;2:349–55.
Madisch A, Heydenreich CJ, Wieland V, et al. Treatment of
functional dyspepsia with a fixed peppermint oil and caraway oil combination
preparation as compared to cisapride. A multicenter, reference-controlled
double-blind equivalence study. Arzen
1999;49(11):925–32.
Magnard G, Franck JP, Dorne PA. Use of tetrahydroxy
flavan-diol in ophthalmology especially in chronic retinopathy (40 cases) [in
French]. Lyon Medical 1970;223(4):259–63.
Marks L, Hess D, Dorey F, et al. Tissue effects of saw
palmetto and finasteride: use of biopsy cores for in situ quantification of
prostatic androgens. Urol
2001;57(3):999–1005.
Marks L, Partin A, Epstein J, et al. Effects of a saw
palmetto herbal blend in men with symptomatic benign prostatic hyperplasia. Jour of Urol 2000 May;163:1451–1456.
Matzner Y, Sallon S. The effect of Padma 28®, a traditional
Tibetan herbal preparation, on human neutrophil function. J Clin. Lab Immunol 1995;46:13–23.
McGuffin M, Hobbs C, Upton R, Goldberg A. American Herbal Product Association’s
Botanical Safety Handbook. Boca Raton (FL): CRC Press;1997.
Medical Products Agency (MPA). Naturläkemedel (Authorised Natural Remedies). Uppsala, Sweden:
Medical Products Agency; 2001.
Mehlsen J, Drabaek H, Peterson JR, Winther K. Der effekt
einer tibetischen krautermischung (Padma 28®) auf die gehstrecke bei stabiler
claudicatio intermittens. Forsc
Komplementarmed 1995;2:240–5. (See also: Angiology 1993;44:863–7.)
Melchart D, Linde K, Worku F, Bauer R, Wagner H.
Immunomodulation with Echinacea—a systematic review of controlled clinical
trials. Phytomed 1994;1:245–254.
Mendal JN, Roy BK. Hepatitis, chronic active hepatitis and
cirrhosis of the liver. Probe
1983;4:217.
Metzker H, Kieser M, Hölscher U. Efficacy of a combined
Sabal-Urtica preparation in the treatment of benign prostatic hyperplasia
(BPH): A double-blind, placebo-controlled, long-term study. Urologe 1996;36:292–300.
Micklefield GH, Greving I, May B. Effects of peppermint oil
and caraway oil on gastroduodenal motility. Phytother
Res 2000;14:20–3.
Miller L. Herbal medicinals: selected clinical considerations
focusing on known or potential drug-herb interactions. Arch Intern Med 1998;158:2200–11.
Moerman D. Native
American Ethnobotany. Portland (OR): Timber Press; 1998.
Moeslinger T, Friedl R, Volf I, Brunner M, Koller E,
Spieckermann PG. Inhibition of inducible nitric oxide synthesis by the herbal
preparation Padma 28® in macrophage cell line. Can J Physiol 2000;78:861–6.
Morazzoni P, Bombardelli E. Valeriana officinalis: traditional use and recent evaluation of
activity. Fitoterapia 1995;66:99–112.
Mori K, Saito Y, Tominaga K. Utility of Hochu-ekki-to® in
general malaise accompanying lung cancer chemotherapy. Biotherapy 1992;6(4):624–7.
MPA. See: Medical Products Agency.
Nefyodov LI, Doroshenko YM, Karavay NL, Brzosko WJ. Effect
of Padma 28® on impaired amino acid metabolism induced by liver inflammatory
pathology. Herba Polonica
2000;XLVI(4):340–5.
Nelson AB, Lau BHS, Ide N, Rong Y. Pycnogenol® inhibits
macrophage oxidative burst, lipoprotein oxidation and hydroxyl radical-induced
DNA damage. Drug Development and
Industrial Pharmacy 1998;24(2):139–44.
Neubauer N, März RW. Placebo-controlled, randomized
double-blind clinical trial with Sinupret® sugar-coated tablets on the basis of
a therapy with antibiotics and decongestant nasal drops in acute sinusitis. Phytomedicine 1994;1(3):177–81.
Niwa M, et al. Effect of Hochu-ekki-to® (TJ-41) on immune
function. Progress in Medicine
1996;16:1506–8.
ORG-MARG Private Limited. Syndicated retail audit conducted
on the Indian Pharma industry. Operations Research Group (ORG) and Marketing
& Research Group (MARG) (ORG-MARG Private Limited); 2001,
Ozaki, Y, Ma, JP. Inhibitory effects of tetramethylpyrazine
and ferulic acid on spontaneous movement of rat uterus in situ. Chem Pharm Bull (Tokyo)
1990;38(6):1620–3.
Packer L, Rimbach G, Virgili F. Antioxidant activity and
biologic properties of a procyanidin-rich extract from pine (Pinus maritima) bark, Pycnogenol. Free Rad
Biol & Med 1999;27(5–6):704–24.
Padma Advertisement. Alternative
Therapies 2000 Sept;6(5):45.
Patney NL, Kumar A. Preliminary Report on the Role of Liv.
52® – An Ayurvedic drug in Serum B hepatitis (Australian Antigen Positive)
cases. Probe 1978;2:132.
Petrassi C, Mastromarino A, Spartera C. Pycnogenol in
chronic venous insufficiency. Phytomedicine
2000;7(5):383–8.
Pinnow R, Egentenmaier J. Controlled clinical trials in
achute (tracheo-) bronchitis: Sinupret® sugar-coated tablets vs. Mucret,
Sinupret® drops vs. Mucosolvan drops in uncomplicated acute (tracheo-)
bronchitis. Abstract presented at the 4th National and 1st International
Congress on Phytomedicine, Munich, 1992.
Pütter M, Grotemeyer KH, Würthwein G, Araghi-Niknam M,
Watson RR, Hosseini S, et al. Inhibition of smoking-induced platelet
aggregation by aspirin and pycnogenol. Thrombosis
Res 1999;95(4):155–61.
Queißer-Luft A., Ismail Ch. Safety of an herbal combination
preparation in pregnancy—an example for using active detection systems for
malformations, abstracts 3rd International Congress on Phytomedicine.
2000;7(2):12.
Reitz, HD. Immunomodulation with phytotherapeutic agents: a
scientific study on the example of Esberitox® [in German]. Notebene medici 1990;20:362–6.
Riechstein A, Mann W. Treatment of chronic rhino-sinusitis
with Sinupret®: a double-blind prospective clinical trial. Schweizerische Zeitschrift fur Ganzheits Medizin 1999;11(6):280–3.
Rihn B, Saliou C, Bottin MC, Keith G, Packer L. From ancient
remedies to modern therapeutics: pine bark uses in skin disorders revisited. Phytotherapy Res 2001;15(1):76–8.
Rohdewald P. Pycnogenol® In: Rice-Evans CA, Packer L,
editors. Flavonoids in Health and Disease.
New York (NY): Marcel Dekker, Inc.; 1998. p. 405–19.
Rohdewald P. A review of the French maritime pine bark
extract (Pycnogenol), a herbal medication with a diverse clinical pharmacology.
Int J Clin Pharm Ther
2002;40(4):158–68.
Roseff SJ, Gulati R. Improvement of sperm quality by
Pycnogenol®. Euro Bull Drug Res
1999;7(2):33–6.
Ruppanner H, Schaefer U, editors. Kräuterpfarrer Künzle AG
Pygenol. In: Codex 2000/01 — Die
Schweizer Arzneimittel in einem Griff. Basel, Switzerland: Documed AG;
2000. p. 459.
Rüve HJ. Identifizierung und Quantifizierung phenolischer
Inhaltsstoffe sowi pharmakologisch-biochemische Untersuchungen eines Extraktes
aus der Rind der Meereskiefer Pinus
pinaster Ait. [doctoral thesis]. Münster, Germany:1996.
Sakamoto T, Mitani Y, Nakajima K. Psychotropic effects of
Japanese valerian root extract. Chem
& Pharm Bull 1992;40:758–61.
Saliou C, Rimbach G, Moini H, McLaughlin L, Hosseini S, Lee
J, et al. Solar ultraviolet-induced erythema in human skin and nuclear
factor-kappa-B-dependent gene expression in keratinocytes are modulated by a
French maritime pine bark extract. Free
Radic Biol Med 2001;30(2):154–60.
Sallon S, Beer G, Rosenfeld J, Anner H, Volcoff D, Ginsburg
G, Paltiel O, Berlatzky Y. The efficacy of Padma 28®, a herbal preparation, in
the treatment of intermittent claudication: a controlled double-blind pilot
study with objective assessment of chronic occlusive arterial disease patients.
J Vasc Invest 1998;4(3):129–36.
Sama SK, Krishnamurthy L, Ramachandran K, Krishnan L.
Efficacy of Liv.52 in acute viral hepatitis: a double-blind study. Indian Journal of Medical Research
1976;5:738.
Samochowiec J, Palacz A, Bobnis W, Lisiecka B. Oscillating
potentials of the electroretinogram in the evaluation of the effects of Padma
28® on lipid metabolism and vascular changes in humans. Phytotherapy Research 1992;6:200–4.
Samochowiec L, Wojcicki J. Effect of Padma 28® on lipid
endoperoxides formation. Herba Polonica
1987;33(3):219–22.
Samochowiec L, Wojcicki J, Kosmider K, et al. Clinical test
of the effectiveness of Padma 28® in the treatment of patients with chronic
arterial occlusion. Herba Polonica
1987;33(1):29–41.
Saur E, Rotival N, Lambrot C, Trichet P. Maritime pine
dieback on the West Coast of France: Growth response to sodium chloride of 3
geographic races in various edaphic conditions. Ann des Sci Forestieres (Paris) 1993;50(4):389–99.
Saxena S, Garg AK, Jain A. A study of Liv.52 therapy in
Infective hepatitis in children. Current
Medical Practice 1980;5:194.
Schilcher H. Personal communication to M. Blumenthal, Dec.
30, 1997.
Schilcher H. Phytotherapy
in Pediatrics: Handbook for Physicians and Pharmacists, 2nd ed. Stuttgart:
Medpharm Scientific Publishers;1997.
Schmidtke I, Schoop W. Hydrostatic oedema and the effect of
medicinal products [in German]. Swiss Med
1984;6(4a):67–9.
Schmidtke I, Schoop W. Pycnogenol—stasis oedma and its
medical treatment [in German]. Z
Ganzheits Med 1995;3:114–5.
Schmitz M, Jackel M. [Comparative study for assessing
quality of life of patients with exogenous sleep disorders (temporary sleep
onset and sleep interruption disorders) treated with a hops-valerian
preparation and a benzodiazepine drug]. Wien
Med Wochenschr 1998;148(13):291–8.
Schneider HJ, Honold E, Masuhr Th. Treatment of benign
prostatic hyperplasia: Results of a surveillance study in the practices of
urological specialists using a combined plant-based preparation (Sabal extract
WS 1473 and Urtica extract WS 1031). Fortschr
Med 1995;113(3):37–40.
Schrader R, Nachbur M, Mahler F. Die Wirkung des tibetischen
krauterpraparates Padma 28® auf die claudicatio intermittens. Schweiz Med Wschr 1985;115.
Schreckenberger F. Die behandlung von epicondylitiden mit
Phytodolor®. Österreichische Zeitschrift fur
Allgemeinmedizin 1988;42:1638–44.
Singh KK, Singh YK, Sinha SK, Sharma V, Mishra BN.
Observatory treatment of infectious hepatitis with Ayurvedic drug - Liv.52. Ind Med J 1977;5:69.
Sirnelli-Walter L, Wiel-Masson D. Therapeutic evaluation of
leucocyanidol (FLAVAN) in venous insufficiency in medical gynaecological
consultation [in French]. Artéres et
Veines 1988;7.
Smulski HS, Wójcicki J. Placebo-controlled, double-blind
trial to determine the efficacy of the Tibetan plant preparation Padma 28® for
intermittent claudication. Alternative
Therapies 1995 July;1(3). Reprinted from: Smulski HS, Wsojcici J.
Plazebokontrollierte doppelblindstudie zur wirkung des tibetanischen
krauterpraparates Padma 28® auf die claudicatio intermittens. Forsch Komplementarmed 1994;1.
Sökeland J, Albrecht J. A combination of Sabal and Urtica
extracts vs. Finasteride in BPH (Stage I and II acc. To Alken): a comparison of
therapeutic efficacy in a one-year double blind study. Urologe 1997;36:327–33.
Spadea L, Balestrazzi E. Treatment of vascular retinopathies
with Pycnogenol®. Phytotherapy Res 2001;15(3):219–23.
Stefanescu M, Matache C, Onu A, Tanaseanu S, Dragomir C,
Constantinescu I, et al. Pycnogenol efficacy in the treatment of systemic lupus
erythematosus patients. Phytother Res 2001;15(8):698–704.
Suter M, Richter C. Anti- and pro-oxidative properties of
PADMA 28®, a Tibetan herbal formulation. Redox
Report 2000;5(1):17–22.
United States Congress (USC). Dietary Supplement Health and
Education Act of 1994, Pub. L. No. 103–417 (1994).
USC. See: United States Congress.
Vonderheid-Guth B, Todorova A, Brattstöm A, Dimpfel W.
Pharmacodynamic effects of valerian and hops extract combination (Ze 9109) on
the quantitative-topographical EEG in healthy volunteers. Eur J Med Res 2000;5:139–44.
Vorberg G. For colds, stimulate the nonspecific immune
system. Arztl Prax 1984;35(6):97–8.
Wang S, Duanjun T, Yusheng Z, Guankai G, Xue G, Hu L. The
effect of Pycnogenol® on the microcirculation, platelet function and ischaemic
myocardium in patients with coronary artery diseases. Eur Bull Drug Res 1999;7:19–25.
Watson RR. Reduction of cardiovascular disease risk factors
by French maritime pine bark extracts. CVR&R
1999 June;326–9.
Wei ZH, Peng QL, Lau BHS. Pycnogenol enhances endothelial
cell antioxidant defence. Redox Report
1997;3(4):219– 24.
WHO. See: World Health Organization.
Winther K, Kharazmi A, Himmelstrup H, Drabaek H, Mehlson J.
Padma 28®, a botanical compound, decreased the oxidative burst response of
monocytes and improves fibrinolysis in patients with stable intermittent
claudication. Fibrinolysis
1994;8(Suppl 2):47–9.
Wójcicki J, Gonet B, Samochowiec L, Gnacin’ska K, Juz’wiak
S. Effect of Padma 28® on ascorbate system in rats receiving a high fat diet. Phytother Res 1989b;3:54–6.
Wójcicki J, Samochowiec L.Controlled double-blind study of
Padma 28® in Angina Pectoris. Herba Pol
1986;32:107–14.
Wójcicki J, Samochowiec L, Ceglecka M, Juzyszyn Z,
Tustanowski S, Kadtubowska D, Juz’wiak S. Effect of Padma 28® on experimental
hyperlipidaemia and atherosclerosis induced by high-fat diet in rabbits. Phytother Res 1988;2:119–23.
Wójcicki J, Samochowiec L, Kadlubowska D. Inhibition of
ethanol-induced changes in rats by Padma 28®. Acta Physiol Pol 1989a;40:387–92.
World Health Organization (WHO). WHO Monographs on Selected Medicinal Plants, vol. 1. Geneva: WHO,
1999.