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Dear Reader
The turmeric root/rhizome and root/rhizome extract Botanical Adulteration Bulletin (BAB), issued in May 2018, is the 14th in the series of bulletins published by the Botanical Adulterants Prevention Program (BAPP). Turmeric is one of the most important spices, and also among the most popular dietary supplement ingredients globally. The increased demand for turmeric extracts and the improvement of laboratory analytical test methods have led to new ways to adulterate the ingredient, such as the addition of synthetically-made curcumin or curcuminoid mixtures. The turmeric bulletin assists lab directors, quality control managers, and others in staying informed on these challenges in order to adjust the identity testing protocols in quality control laboratories.
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Stefan Gafner, PhD
Chief Science Officer, ABC
Technical Director, ABC-AHP-NCNPR Botanical Adulterants Program |
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ABC-AHP-NCNPR Botanical Adulterants Prevention Program
Recent News
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Turmeric Root/Rhizome and Extract Bulletin Published by the Program
In May the ABC-AHP-NCNPR Botanical Adulterants Prevention Program released the Botanical Adulterants Bulletin (BAB) on turmeric adulteration. Turmeric (Curcuma longa, Zingiberaceae) dietary supplements have seen a steady increase in sales in the United States and other parts of the world.
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Botanical Adulterants Prevention Program Releases Boswellia Bulletin
Dietary supplements made with extracts of the oleogum resin of boswellia (Boswellia serrata, Burseraceae), an important medicinal plant in the Ayurvedic medicine system in India, have shown one of the highest sales growth rates in the United States over the past five years. At the same time, reports have emerged that some products sold as Boswellia serrata extracts are actually made from other Boswellia resins, or from resins of altogether different genera of trees.
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ABC-AHP-NCNPR Botanical Adulterants Prevention Program Welcomes New Supporters and Underwriters
The ABC-AHP-NCNPR Botanical Adulterants Prevention Program is grateful to the following companies that have recently committed to financially underwriting the Program:
- Biotropics Malaysia
- Designs for Health
- Trust Transparency Center
- XYMOGEN
The following trade associations have also joined as supporters of BAPP recently:
- Global Curcumin Association (GCA)
- Natural Astaxanthin Association (NAXA)
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Regulatory Alerts
CSPI Calls for FDA Enforcement Action Against Adulterated Ginkgo Extract Products
In a letter signed by Laura MacCleery, Director of Regulatory Affairs for the Center for Science in the Public Interest (CSPI), the consumer advocacy group requested the US FDA to act against the sale of adulterated ginkgo leaf extract products.
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Industry Alerts
Evidence for Adulteration of Ginkgo Leaf Extracts from Europe
Details of the investigation into the quality of 15 ginkgo leaf dietary supplements by the Sydney, Australia-based Network Nutrition-IMCD (summarized in the previous Botanical Adulterants Monitor) have now been published. The results from this evaluation of commercial mono-herbal formulations containing Ginkgo biloba leaf extracts, sourced from stores in Europe can be requested from the company (networknutrition@imcd.com.au) according to a press-release from May 7, 2018.
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Upcoming Events
Below are descriptions and links to some of the upcoming conferences, seminars, and workshops that may be of interest to learn more on adulteration.
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Previous Issues of “Botanical Adulterants Monitor”
Available here. |
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Science Update
Isotopic Fingerprinting and NMR Analysis Detects Designer Blends Made with Animal Fats Marketed as Saw Palmetto Extracts
Reviewed: Perini M, Paolini M, Camin F, Appendino G, Vitulo F, De Combarieu E, Sardone N, Martinelli EM, Pace R. Combined use of isotopic fingerprint and metabolomics analysis for the authentication of saw palmetto (Serenoa repens) extracts. Fitoterapia.2018;127:15-19.
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HPTLC and UHPLC-MS Analysis of Commercial Cranberry Products
Reviewed: Boudesocque-Delaye L, Arnaud Lanoue A, Dorat J, Bruyère F, Gueiffier A, Enguehard-Gueiffier C. Quality control of commercial cranberry products: HPTLC-densitometry a new deal. Food Control. 2018;86:214-223.
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Analysis of Flavonoid and Terpene Lactone Contents in European Ginkgo Dietary Supplements Once Again Reveals Quality Issues and Adulteration
Reviewed: Czigle S, Tóth J, Jedlinszki N, Háznagy-Radnai E, Csupor D, Tekelová D. Ginkgo biloba food supplements on the European market – Adulteration patterns by quality control of selected samples. Planta Med. 2018;84(6-7):475-482. doi: 10.1055/a-0581-5203.
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HPTLC and DNA Metabarcoding Analysis of 53 Commercial Echinacea Dietary Supplement Products
Reviewed: Raclariu AC, Ţebrencu CE, Ichim MC, Ciupercǎ OT, Brysting AK, De Boer H. What's in the box? Authentication of Echinacea herbal products using DNA metabarcoding and HPTLC. Phytomedicine. 2018;44:32-38.
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A HPTLC Fingerprinting Method for the Authentication of Angelica gigas and Other Important Apiaceae Members
Reviewed: Frommenwiler DA, Kim J, Yook C-S, Tran TTT, Cañigueral S, Reich E. Comprehensive HPTLC fingerprinting for quality control of an herbal drug – the case of Angelica gigas root. Planta Med. 2018;84(6-7):465-474. doi: 10.1055/a-0575-4425.
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Low-Field NMR as a Complementary Tool to Detect Patchouli Oil Adulteration
Reviewed: Krause A, Wu Y, Tian R, van Beek T. Is low-field NMR a complementary tool to GC‑MS in quality control of essential oils? A case study: Patchouli essential oil. Planta Med. 2018; Apr 24. doi: 10.1055/a-0605-3967. [Epub ahead of print]
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Useful Links and Resources
For more information and updates on the work of the three partner organizations of the ABC-AHP-NCNPR Botanical Adulterants Program, please visit ABC at www.herbalgram.org, AHP at www.herbal-ahp.org, and NCNPR at www.pharmacy.olemiss.edu/ncnpr.
Other Helpful Resources and Links
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About the
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The ABC-AHP-NCNPR Botanical Adulterants Program is a consortium of independent nonprofit organizations whose mission relates to education, scientific research, and quality of botanical dietary ingredients and related plant-derived materials. The consortium is headed by three nonprofit groups dealing with education and research on medicinal herbs and other beneficial plants: the American Botanical Council, the American Herbal Pharmacopoeia, and the National Center for Natural Products Research at the University of Mississippi. The program is underwritten or endorsed by more than 130 natural products industry companies, independent analytical laboratories, contract research organizations, nonprofit and professional organizations, trade associations, accredited institutions of education in natural medicine, law firms, and media companies that are involved in the production, supply, manufacture, distribution, marketing, analysis, research, and/or education of herbal dietary ingredients and supplements, in the United States and internationally. All publications of the Program are available free-access on its homepage including the “Botanical Adulterants Monitor,” an e-newsletter that conveys Program news, regulatory updates, and recent scientific publications related to adulteration, contamination, identity, and authenticity of botanical raw materials, extracts, and essential oils. Companies, organizations, foundations, and/or individuals interested in supporting this program are invited to contact Ms. Denise Meikel, ABC Development Director, at (512) 926-4900, ext. 120, or by email.
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Thank You to Our Supporters
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Underwriters and Supporters of the ABC-AHP-NCNPR Botanical Adulterants Program (as of August 3, 2018)*
*By acknowledging the generous support of these companies and organizations, ABC, AHP, and NCNPR are not endorsing any ingredients or products that may be produced or marketed by them.
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Financial Underwriters
221st Century Healthcare
AdvoCare International L.P.
Agilent Technologies, Inc.
Aloecorp, Inc.
Amen Clinics
Amway/Nutrilite Health Institute
Arbonne International
Arizona Nutritional Supplements
Artemis International, Inc.
Atrium Innovations
Aveda Corporation
Beachbody, LLC
BI Nutraceuticals
Bioceuticals
Bionorica SE
Biotropics Malaysia
Blackmores
Botanical Liaisons
Bruker BioSpin
Capsugel
Cepham, Inc.
Chemi Nutra
CNCA Health
Complete Phytochemical Solutions
Crila Health
Designs for Health
dicentra, Inc.
Doctor’s Best
Dr. Bronner's Magic Soaps
DolCas Biotech, LLC
dōTERRA International, LLC
Douglas Laboratories
Draco Natural Products
ECONET, Inc.
Emerson Ecologics
Enzymatic Therapy, Inc.
Ethical Naturals, Inc.
Eu Yan Sang International
EuroMed
EuroMedica
EuroPharma
Flavex Naturextrakte GmbH
Flordis
FoodState/MegaFood
Fruit d’Or
Gaia Herbs
GE Nutrients, Inc.
Ginsana SA
Global Health Industries
GNC, Inc.
Healthy Lifestyle Brands, LLC
Helios Corp.
Herb Pharm
Herbalife International, Inc.
Horphag Research
iHerb
Indena USA, Inc.
Indfrag Limited
Ingredient Identity
IVC
Ixoreal Biomed Inc.
Jarrow Formulas
Klaire Labs
Layn USA, Inc.
Linnea
Markan Global Enterprises, Inc.
Martin Bauer, Inc.
MediHerb / Integria Healthcare
Metagenics, Inc.
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Financial Underwriters
(cont'd)
Natreon, Inc.
Natrol
Natural Alternatives International, Inc.
Natural Factors Nutritional Products, Inc./Bioclinic Naturals
Natural Grocers by Vitamin Cottage
Natural Partners, Inc.
Natural Remedies Pvt. Ltd.
Nature's Sunshine Products
Nature's Way
Naturetech
Naturex, Inc.
NBTY, Inc.
Network Nutrition – IMCD
New Chapter, Inc.
The New Frontier Foundation Fund of the Greater Cedar Rapids Community Foundation
Ningbo Greenhealth Pharmaceutical Co., Ltd.
Novel Ingredients
NOW Health Group
Nu Skin Enterprises/Pharmanex
Nutraceutical Corp
OmniActive Health Technologies, Inc.
Organic India
Ortho Molecular Products
Pacific Nutritional Inc.
Paragon Laboratories
Pathway International Pty Limited
Perrigo Company
Pharmatoka SAS
Pharmavite, LLC
Phoenix Formulations
PLT Health Solutions, Inc.
Polyphenolics, Division of Constellation Brands, Inc.
Potter’s
ProThera
Pure Encapsulations
Rainbow Light Nutritional Systems
RFI Ingredients, LLC
Rosenbush and Zimmerman Family Fund
Sabinsa Corporation
Schwabe North America
Seroyal
SFI Research
Shaklee Corp.
Soho Flordis International
SOHO Global Health
Standard Process, Inc.
Strategic Sourcing, Inc.
Thorne Research, Inc.
Tishcon Corp.
Traditional Medicinals, Inc.
Trust Transparency Center
TSI Group
Unigen
Univera, Inc.
Valensa International
V.D.F. FutureCeuticals
Verdure Sciences
Vitamin Shoppe
VitaQuest International
Whole Foods Market
XYMOGEN
ZMC-USA
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Trade Associations
American Herbal Products Association (US)
Australian Self Medication Industry (Australia)
Australian Tea Tree Industry Association (Australia)
British Herbal Medicine Association (UK)
Canadian Health Food Association (Canada)
Complementary Medicines Australia (Australia)
Consumer Healthcare Products Association (US)
Council for Responsible Nutrition (US)
Global Curcumin Association (GCA)
International Alliance of Dietary/Food Supplement Associations (IADSA)
National Animal Supplement Council (US)
Natural Astaxanthin Association (NAXA)
Natural Products Association (US)
Natural Products New Zealand (NZ)
United Natural Products Alliance (US)
Nonprofit/Professional Associations
Academy of Integrative Health & Medicine
American Association of Naturopathic Physicians
American Herbalists Guild
American Society of Pharmacognosy
AOAC International
Council of Colleges of Acupuncture and Oriental Medicine
Homeopathic Pharmacopoeia Convention of the United States
Integrative Healthcare Policy Consortium
Irish Register of Herbalists (IRE)
National Institute of Medical Herbalists (UK)
Natural Health Products Research Society of Canada (NHPRS Canada)
Personalized Lifestyle Medicine Institute
Society for Medicinal Plant and Natural Product Research (GA)
Colleges/Universities
Bastyr University
Boucher Institute for Naturopathic Medicine
Center for Natural Products Technologies, College of Pharmacy, University of Illinois-Chicago
Hong Kong Baptist University’s School of Chinese Medicine
Maryland University of Integrative Health
National College of Natural Medicine
Southwest College of Naturopathic Medicine
University of Bridgeport College of Naturopathic Medicine
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Third-Party Analytical Laboratories
Alkemist Labs
NSF AuthenTechnologies
Bent Creek Institute
BotaniCert (France)
British Columbia Institute of Technology
Creative Accord, LLC
Eurofins Scientific Inc.
Flora Research Labs
NSF International
PhytoLab (Germany)
Spectrix Labs
Tampa Bay Analytical
Media
Alive Publishing Group
Delicious Living
Engredea
Holistic Primary Care
IMPACT Health Media, Inc.
Informa Exhibitions US
Integrator Blog
Media Relations, Inc.
Modern Healthcare Practitioner
Natural Foods Merchandiser
Natural Medicine Journal
Natural Products INSIDER
Newhope360.com
Nutraceuticals World
NutraingredientsUSA.com
Nutrition Business Journal
Nutrition Industry Executive
Nutritional Outlook
Vitamin Retailer
WholeFoods Magazine
Law Firms & Regulatory Consultants
AAmin Talati & Upadhye, LLC
Greenberg Traurig, LLP (James Prochnow)
Law Office of Holly Bayne, P.C.
Robert Forbes & Associates
Susan Brienza, LLC
Ullman, Shapiro & Ullman, LLP
Contract Research Organizations
KGK Synergize
Research Institutes
Korean Ginseng Research Institute
Shanghai Research Center for TCM Modernization/Shanghai Institute of Materia Medica of the Chinese Academy of Sciences
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