FWD 2 Commission E: Saffron

  The Commission E Monographs

Saffron


Croci stigma
Safran
Published April 23, 1987

Name of Drug

Croci stigma, saffron.  

Composition of Drug

Saffron consists of the stigmata, usually connected by a short piece of pistil, of Crocus sativa L.  [Fam.  Iridaceae], as well as preparations thereof.  

Uses

Saffron is used as a sedative, for spasms and asthma.  

The effectiveness of the herb for its claimed applications has not been documented.  

Risks

Presently, no risks have been documented for a maximum daily dosage of 1.5 g.  The lethal dosage is 20 g; the abortifacient dosage is 10 g.  

From the administration of saffron as an abortifacient, the following effects have been observed:

Severe purpura after ingestion of 5 g of saffron (suspended in milk) with pitch black necrosis of the nose and a thrombocytopenia of 24,000, hypothrobinemia of 41 percent and severe collapse with uremia.  

Additionally: bleeding of the uterus, bloody diarrhea, hematuria, bleeding from the nose, lips and eyelids, vertigo, dizziness, numbness.  Yellowing of the sclera, skin and mucous membranes, a condition that may falsely imply icterus.