By Hannah Bauman
On
April 16, 2018, the American Herbal Pharmacopoeia (AHP) announced the
publication of monograph standards and a therapeutic compendium for motherwort
(Leonurus cardiaca and L. quinquelobatus, Lamiaceae) aerial
parts. Motherwort aerial parts have been used in Asian healing traditions for
approximately 2,500 years, with documented uses in the Western tradition dating
back to the 15th century. The plant’s common name refers to its widespread use
as a childbirth aid and menopause aid, and for gynecological and reproductive
issues. Clinical trials of motherwort also have investigated its potential therapeutic
use in patients with hypertension, cardiac palpitations, and anxiety. The
aerial parts of motherwort, a member of the mint family, can be prepared as a tisane,
tincture, dry extract, or fluid extract, though they are most commonly sold as tisanes
or tinctures.
The
AHP monograph establishes authenticity, purity, and quality standards for raw
materials and preparations. The therapeutic compendium provides a comprehensive
review of pharmacological and safety data, including information on
pharmacokinetics, pharmacodynamics, actions, medical indications, modern and
traditional uses, structure and function claims, dosages, interactions, side
effects, contraindications, toxicology, and more.
The
publication is the result of a collaboration among AHP and researchers from the
University Medical Center Göttingen in Germany; the Poznan University of
Medical Sciences, Department of Pharmacognosy in Poland; the University of
Medicine and Pharmacy Department of Pharmacognosy, Phytochemistry, and Phytotherapy in Bucharest, Romania; the University of Vienna in Austria; and
the University of Reading in England. The publication’s 12 authors and 19
reviewers are international experts from China, Kazakhstan, Uzbekistan, Russia,
Austria, and the United States.
The
macroscopic identification section of the monograph contains detailed,
close-up, labeled photographs of fresh and dried motherwort aerial parts to aid
field workers and others who handle raw materials. For comparison purposes,
this section also includes photographs of Asian motherwort (L. japonicus), which is not accepted as
an official motherwort species in Europe, the United States, or Russia.
However, L. japonicus is listed in
the official pharmacopeias of China, Germany, Japan, and Korea, which has
resulted in some confusion in the international market. While these plants have
very similar traditional uses, the monograph provides information about the
methods to determine their morphological, chemical, and pharmacological
differences.
The
evolving nomenclatural and taxonomic discussion also notes that L. quinquelobatus was once considered a
subspecies of L. cardiaca but is
currently treated as its own separate species; this, however, is a recent
taxonomic change that is not reflected in the American Herbal Products
Association’s Herbs of Commerce, 2nd
edition. AHP President Roy Upton, the lead author of the monograph, takes great
care to point out these taxonomic intricacies, and notes that L. quinquelobatus should not be
considered an adulterant if it appears in a motherwort product.
In
AHP’s press release that announced the monograph and therapeutic compendium’s
publication, Upton was quoted as saying: “Motherwort is an underutilized
botanical. Thanks to many international collaborators, this monograph
represents the most complete body of information on motherwort to date.”1
Motherwort
is used mostly by traditional herbalists, particularly those with female clients.
It has yet to appear, for example, in market data compiled by Chicago-based
marketing firms SPINS and IRI as reported by the American Botanical Council’s
(ABC’s) annual Herb Market Report. The report provides lists of the 40 top-selling
botanicals in both the natural and mainstream market segments. However, with
recent clinical studies investigating motherwort’s potential antihypertensive
and anxiolytic actions, the botanical could be poised for an increase in
popularity among consumers.
AHP’s
monograph and therapeutic compendium provides information that can be used by a
variety of individuals in the herbal community, from consumers and
practitioners to quality control personnel and dietary supplement
manufacturers.
ABC
Chief Science Officer Stefan Gafner, PhD, praised AHP’s extensive work on the
monograph and therapeutic compendium and congratulated the organization for giving
attention to a relatively unknown herb (email, May 8, 2018). “This is another
extraordinary AHP monograph on an important medicinal herb that has not been
considered by other standard-setting organizations,” Gafner wrote. “The
document covers the important aspects of the herb in detail, and it even has a
separate section on the history of the plant at the end. I found the images and
text for the macroscopic identification simply outstanding and believe that
this part will be highly beneficial since the botanical material is still
predominantly wild-crafted. Overall, this monograph will appeal to a broad
audience, not only those who manufacture motherwort dietary supplements, but
also those who use it in their medical practice.” The monograph is available for purchase through the AHP website.2
Image credits (top to bottom): AHP logo
Leonurus cardiaca aerial parts, ©2018 Steven Foster
Leonurus japonicus aerial parts, ©2018 Steven Foster
Reference
- AHP
Releases Monograph Standards, Motherwort Aerial Parts (Leonurus cardiaca; Leonurus
quinquelobatus) Monograph and Therapeutic Compendium. [press release]
Scotts Valley, CA: American Herbal Products Association. April 16, 2018.
Available at: http://herbal-ahp.org/documents/press_releases/Motherwort%20PR%202018.pdf.
Accessed April 30, 2018.
- Secure online ordering. American Herbal Pharmacopoeia website. Available at: http://herbal-ahp.org/order_online.htm. Accessed May 9, 2018.
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