Issue:
112
Page: 8-17
Passionflower
Passiflora incarnata L.
Family: Passifloraceae
by Gayle Engels, Josef Brinckmann
HerbalGram.
2016; American Botanical Council
INTRODUCTION
Commonly known as
passionflower, purple passion flower, or maypop, Passiflora incarnata is one of
approximately 520 species in the family Passifloraceae. Species in this family
are found primarily in Central and South America, and, less commonly, in North
America, Australia, and Southeast Asia.1 Growing up to 25 feet in
length, passionflower is an herbaceous vine that climbs using axillary
tendrils, and it spreads aggressively by root suckers. It has deciduous (or
evergreen, depending on the climate), three-lobed, dark green leaves that are
whitish on the underside. Conspicuous, largely lavender corona flowers with
showy pistils and stamens appear in spring through fall and are followed by
yellow edible fruit (berries).2
Passiflora incarnata is native to the southeastern
United States3 and is currently distributed from Florida west to
Texas, north to southeastern Kansas, and east to Virginia,4 where it
is cultivated in gardens and found in disturbed sites, along fences, by
roadsides, in thickets, and on waste grounds.1 The northern limits
of passionflower’s current range are an extension of its original habitat due
to increasing anthropogenic effects (i.e., the influence of human activities on
nature). Archeological evidence indicates, for example, that P. incarnata did not occur in
Arkansas or Kentucky prior to the 1550s.4 In the 17th century, European
colonizers brought P.
incarnata to Europe, where it was introduced, domesticated, and is
still cultivated today, particularly in Mediterranean France and Italy, where
there are several certified organic farms growing passionflower for the herbal
market.
While some of the
material of commerce is obtained from cultivation in the United States and
parts of southern Europe, much of the commercial supply of passionflower is
still wild-collected in the southeastern United States. The entire vine, including
stems, leaves, flowers, and fruits, is harvested by hand starting in the late
spring (when it begins to flower) from disturbed areas, fields, and early
successional habitats.5*
Although the second
edition of the American Herbal Products Association’s Herbs of Commerce
also lists other passionflower species — namely, P. caerulea (blue
passionflower), P. coriacea
(bat-leaf passionflower), P. edulis (purple granadilla or purple
passionflower), P. foetida
(stinking passionflower), and P. laurifolia (yellow granadilla or bay-leaf
passionflower)6 — this article focuses on P. incarnata.
HISTORY AND CULTURAL SIGNIFICANCE
Historically,
various P. incarnata
plant parts have been used as food or medicine by Native American tribes in the
southeastern United States, including the Apalachee and Creek (both of
Florida),7 Cherokee (Georgia, North and South Carolina, Tennessee,
Virginia), Houma (Louisiana),8 and Powhatan (Virginia).9
Seeds of P. incarnata
are often found among archaeobotanical artifacts at excavation sites (e.g., at
the Early Historic North American archaeological period [17th century] Creek
town of Fusihatchee in Alabama, and at several Apalachee sites in North
Florida).7 According to archeological evidence, human use of P. incarnata began in the Late
Archaic period (3,500-800 BCE) in North America. Seeds have been identified at
Late Archaic period sites in Alabama and Tennessee; Early Woodland period (800
BCE-200 CE) sites in Georgia; Middle Woodland period (100 BCE-550 CE) sites in
Alabama and Tennessee; Late Woodland period (550-1000 CE) sites in Alabama,
Louisiana, and Tennessee; Mississippian/Protohistoric period (1000-1550 CE)
sites in Alabama, Georgia, North and South Carolina, Tennessee, Mississippi,
and Virginia; and Historic period (1550-1800 CE) sites in Georgia, North
Carolina, and Tennessee.4
In his manuscript The
Historie of Travaile Into Virginia Britannia, William Strachey, an English
writer who served as the first Secretary of the Colony of Virginia in 1610,
documented Algonkian food uses of wild passionflower fruits, which the
indigenous referred to as “maracock,” in coastal Virginia.10 It has
been suggested that the origin of one of passionflower’s common names “maypop” is
an alteration of “maycock,” a name derived from the Powhatan (Virginia) name “mahcawq.”
But the name may also refer to the sound made when the buds begin popping in
the month of May, or to the popping sound that is made when the fruits are
crushed or stepped on.7
The genus name Passiflora and the
corresponding vernacular name “passionflower” originate from the Italian fiore della passione, a name
given to the flower in a context of Christian symbology (objects associated
with the crucifixion of Christ).4 This story can be traced back to
1605 CE at the start of the papacy of Pope Paul V (1552–1621), when a live P. incarnata plant was given to
the pope and planted as a gift in his honor. First described in a treatise on
New World flora written by the Italian Dominican monk Simone Parlasca and
published in 1609,11 as well as in a 1619 publication by Neapolitan
Dominican monk and druggist Fra Donato d’Eremita,12 the flower’s
corona was represented as resembling the crown of thorns, the three styles
being the nails of the cross, the three-lobed leaves the spear, and the five
anthers representing the marks of the five wounds, among other correlations.13
Passionflower was first introduced into England in 1629 as a greenhouse plant
later described in a folio (pamphlet) titled Six Numbers of Coloured Figures
of Passion Flowers by Mary Lawrance.14
In 1838, W.B.
Lindsay of Bayou Gros Tête,
Louisiana, brought the clinical use of inspissated (thickened or congealed)
passionflower juice to the attention of his friend David Lewis Phares of
Newtonia, Mississippi, after having prescribed it for 30 years (since about
1808) with reportedly successful outcomes in cases of tetanus neonatorum.†
In his early years of dispensing passionflower juice, Lindsay had
attributed observed differences in dosage strength and efficacy to an incorrect
assumption that preparations were being made from different species of Passiflora. He was later
convinced that the medicines had all been made from P. incarnata but that the
differences were due to dissimilarities in season of gathering, mode of
preparation, and locality of growth. (For example, Lindsay believed that
passionflower wild-collected on uplands and in Bayou Gros Tête made the strongest medicine, while
passionflower collected near dikes or levees around New Orleans was inferior.)
Later, in their clinical practices, both Phares and his son, J.H. Phares,
reported success using passionflower juice to treat tetanus erectus
in horses.14 D.L. Phares reportedly also carried out human trials,
published in the New Orleans Medical Journal, using passionflower
preparations made by Lindsay.
In the late 19th
century, Isham Jabus Marshall Goss, MD (1819-1896), of Georgia introduced the
use of passionflower into Eclectic medical practice. According to the 18th
edition of King’s American Dispensatory (3rd Revision), published in
1898, specific indications for use of passionflower liquid extracts in the
Eclectic system of medicine included “irritation of brain and nervous system
with atony; sleeplessness from overwork, worry, or from febrile excitement, and
in the young and aged; neuralgic pains with debility; exhaustion from cerebral
fullness or from excitement; convulsive movements; infantile nervous
irritation; nervous headache; tetanus; hysteria; oppressed breathing; cardiac
palpitation from excitement or shock.”15
Traditional European
uses of the plant include for anxiety, constipation, indigestion, insomnia,
nervousness, and mild infections.1 In Poland, it has been used for
hysteria and neurasthenia, while, in Turkey, in addition to insomnia, it has
been used for epilepsy, painful menstruation (dysmenorrhea), neuralgia, and
neurosis.1
Defined as the dried
herbage of “Passiflora
incarnata Linné” collected after some of the berries have matured, “Passiflora” entered the fourth
edition of the National Formulary (NF IV) in 191616 and
remained officinal through the fifth edition (NF V) until 1936. A monograph for
“Tinctura Passiflorae”
was also included in the NF V.17 The 20th edition of The
Dispensatory of the United States of America, published in 1918, added
monographs describing both “Passion Flower N.F.” and “Tinctura Passiflorae N.F.”18
In 1975, the US Food
and Drug Administration (FDA) considered inclusion of “passion flower extract” as
a sedative active ingredient in its proposal to establish a monograph for
over-the-counter (OTC) nighttime sleep-aid and daytime sedative drug products.
Although “passion flower extract” was a labeled active ingredient in marketed
sedative drug products at that time, the FDA’s Advisory Review Panel on OTC
Sedative, Tranquilizer and Sleep-Aid Drug Products was unable to find
sufficient evidence to demonstrate that it induced sedation. The panel
initially classified the use of passion flower extract in nighttime sleep-aid
products as “irrational.”19
In 1978, while still included in the ongoing review of nighttime sleep-aid
active ingredients, the FDA issued a tentative final order placing passion
flower extract into Category II, meaning “nonmonograph” or “Not Generally
Recognized as Safe and Effective” (not GRASE).20
Another
eleven years passed before the FDA would issue its final rule in 1989, which
classified passion flower extract as nonmonograph. OTC nighttime sleep-aid drug
products containing passion flower extract could no longer be marketed unless
the product was the subject of an approved New Drug Application (NDA). Existing
passionflower drug products were then required to be phased out of the market.21
By the time the Dietary Supplement Health and Education Act (DSHEA) of 1994 was
passed, passionflower-based products were transitioned from OTC drug to the
newly established dietary supplement framework. In 2000, the FDA ruled that some
OTC drug monograph claims would be acceptable as structure-function claim
statements, including claims listed in its nighttime sleep-aid monograph (in
particular, “for the relief of occasional sleeplessness,” because occasional
sleeplessness is not a characteristic symptom of a disease).22 In
this case, it turned out that certain passionflower-based dietary supplements
could now be marketed with the same claim statement as when previously labeled
and marketed as OTC sleep-aid drug products, provided that the notifying
company had compiled a substantiation file containing sufficient levels of
evidence to support the claim for its specific product.
In
1985, the German Commission E approved the use of passionflower herb, prepared
as an herbal tea infusion or equivalent galenical preparation, as a
nonprescription medicine for treating nervous restlessness.23 Since
then, national labeling standards monographs of European Union (EU) member
states, such as those of the German Commission E, have been superseded by
monographs of the European Medicines Agency (EMA). In Germany, the aerial parts
(herb) of P. incarnata remains
classified as both medicine and food (depending on dose) and appears on List B
in Germany’s List of Substances, meaning that restricted use in foods is
recommended because pharmacological effects occur above a certain dose.24
A
quality standards monograph for “Passiflorae Herba”
first entered the European Pharmacopoeia (PhEur)
in the 2000 supplement to the 1997 third edition25 and has remained
official through the current ninth edition published in July 2016.26
In 2007, a comprehensive monograph (quality and therapeutics) for “Herba Passiflorae” entered volume three of the WHO Monographs on
Selected Medicinal Plants.27 In the same year, the EMA published
a labeling standards monograph (later superseded by a 2014 revised monograph),28
and the following year, Health Canada published its labeling standards
monograph.29 Although a quality standards monograph for “Pasiflora,
Parte Aérea” entered the Mexican Pharmacopoeia in 2013,30 remarkably there is not yet an
official quality standards monograph available in the United States Pharmacopeia(USP) for this widely used medicinal plant that is
native to the United States.
Currently,
herbalists employ P. incarnata for its
analgesic, antispasmodic, hypnotic, nervine, and hypotensive effects. It has
proven useful as a sedative for intractable insomnia, for relieving nerve pain,
and for addressing seizures and asthma associated with spasms and tension.31
An
online retrospective survey of the use of herbal anxiolytics by college
students published in 2012 revealed that passionflower was the most commonly
used herbal dietary supplement for reducing anxiety. Of 235 students who
responded, 85 (36.2%) used passionflower in the previous 12 months (of those 85
students, 55 used it less than 10 times, 19 used it monthly, nine weekly, and
two daily).32 The most common reasons given for using an herbal
dietary supplement were recommendation by friends or family (38%), ease of
obtaining dietary supplement (36.3%), and lower cost compared to prescription
drugs (23.1%).
CURRENT AUTHORIZED USES IN COSMETICS, FOODS, AND MEDICINES
In the United
States, passionflower may be used as a natural flavoring substance, so long as
the minimum quantity to produce the intended effect is used.33 (The
FDA regulation specifically lists “passion flower [Passiflora incarnata L.],” but it
may be safe to assume that passionflower fruit and extracts thereof are
included in the scope of the regulation.) Passionflower is also permitted as a
component of dietary supplement products, requiring FDA notification within 30
days of marketing if a structure-function claim is made and product
manufacturing according to dietary supplement current good manufacturing
practices (cGMPs).34
In Canada,
passionflower is regulated as an active ingredient of licensed natural health
products (NHPs) requiring pre-marketing authorization from the Natural and
Non-prescription Health Products Directorate (NNHPD). Labels of licensed NHPs
prepared from British or European pharmacopeial-quality passionflower may carry
the claim statement “Traditionally used in Herbal Medicine as a sleep aid (in
cases of restlessness or insomnia due to mental stress).”30
Additionally, passionflower is listed in the draft “Cognitive Function Products”
monograph as a sedative active ingredient.35 At the time of this
writing (September 2016), 547 licensed NHPs list P. incarnata as an ingredient,
of which 543 products list it as a medicinal ingredient, and four NHPs list it
as a non-medicinal ingredient.36
For herbal medicinal
product companies in the EU, or in non-EU countries where the PhEur is an
official compendium (e.g., Australia and Canada), there are quality standards monographs
established by the European Directorate for the Quality of Medicines (EDQM) for
“Passion Flower Herb” containing a minimum of 1.5% flavonoids (expressed as
vitexin), and “Passion Flower Dry Extract” containing a minimum of 2.0%
flavonoids (expressed as vitexin), which can be used as the basis for active
ingredient specifications.29 Registered Traditional Herbal Medicinal
Products (THMPs) composed of PhEur-quality passionflower and prepared as herbal
teas, liquid extracts, or as solid dosage forms containing dry extract, may be
labeled and marketed “for relief of mild symptoms of mental stress and to aid
sleep.”28
For use in cosmetic
products, the European Commission Health and Consumers Directorate lists “Passiflora Incarnata Extract” (extract of whole plant) for astringent function. “Passiflora Incarnata Flower Extract” is listed for skin-conditioning and skin-protecting functions, and “Passiflora Incarnata Water” (aqueous
solution of the steam distillates obtained from passionflower) is listed for
masking and skin-conditioning functions.37
MODERN RESEARCH
Passiflora incarnata herb contains 1-2.5% flavonoids
(pharmacopeial quality contains minimum 1.5% flavonoids, expressed as vitexin),
consisting almost exclusively of C-glycosyl flavones. The proportion of each
individual flavonoid is, however, highly variable. For example, isovitexin-2”-O-glucoside
is present at 0.1 to 0.8%, isoshaftoside at 0.05 to 0.5%, shaftoside at 0.02 to
0.61%, and isoorientin-2”-O-glucoside at 0.1 to 0.46%, and in some types
swertisin is present (at about 0.3%). There are only small amounts of vicenin-2
and lucenin-2, and very low levels of orientin and vitexin. Passionflower also
contains polysaccharides (especially arabinoglucan), free amino acids including
gamma-aminobutyric acid (GABA), and trace amounts of harmala alkaloids.38
Wohlmuth et al. (2010) attribute the high variability of flavonoid levels in
different samples to the existence of two distinct chemotypes. The type that
contains swertisin is almost absent of shaftoside and isoshaftoside.39
In vivo and in vitro
studies of P. incarnata show limited support of its anti-anxiety, antiasthmatic, anticonvulsant, antidiabetic, antiseizure, antitussive, and sedative properties.1,40-44
Passionflower is
primarily used in combination with other herbs, and clinical evidence of its
efficacy as a monopreparation is limited. There are, however, at least six
clinical studies on P. incarnata alone for conditions including
anxiety, sleep, and attention deficit hyperactivity disorder (ADHD).
In a randomized,
single-blind study from 2013, 63 patients needing periodontal treatment were
randomly assigned into one of three groups of 21 to test the efficacy of
passionflower in reducing dental anxiety. One group was given 20 drops of
passionflower extract (Pasipay, 30% hydroalcoholic extract with total flavonoid
content of 4% w/w, including vitexin and rutin; Iran Darouk Pharmaceutical Co.;
Tehran, Iran) the night before treatment and 20 drops following treatment. In
the placebo group, the placebo drops were administered in the same way. The
third group received no intervention. Patients filled out the Corah’s Dental
Anxiety Scale, Revised (DAS-R) at the initial interview and following the
intake of medication before periodontal treatment. The passionflower group
experienced a significant reduction in anxiety following administration of the
drops, from 12.09 ± 2.42 down to 8.47 ± 2.08 (P < 0.0001). There was
no significant reduction in anxiety in the other two groups.45
A randomized,
double-blind, placebo-controlled (RDBPC) prospective study published in 2011
investigated the effect of passionflower on preoperative anxiety. Forty-five
minutes prior to receiving spinal anesthesia, 60 patients completed both parts
of the State-Trait Anxiety Inventory (STAI) questionnaire to measure basic
anxiety and induced anxiety. Sedation level and psychomotor function were also
measured. Thirty minutes prior to receiving anesthesia, hemodynamics were
measured via heart rate and systolic, diastolic, and mean arterial pressures,
and the patients were randomly assigned to two groups. Patients received either
passionflower syrup (700 mg/5 mL aqueous extract; Sandoz, Kocaeli, Turkey; no
additional information provided) or placebo. All of the tests were performed
again just prior to administration of anesthesia, and there was a statistically
significant increase in STAI scores in the placebo group but no other
statistically significant differences. The authors state that oral
administration of P. incarnata suppresses the increase in anxiety before spinal
anesthesia without affecting psychomotor function, sedation level, or
hemodynamics.46
Another
RDBPC study published in 2008 evaluated the efficacy of passionflower in
reducing preoperative anxiety. Sixty patients scheduled for inguinal
herniorrhaphy (surgical repair of a hernia in which a loop of the intestine has
protruded through a weak area of the adominal wall) were randomly assigned into
one of two groups. One group received 500 mg of Pasipay 90 minutes before
surgery; the other received placebo. Each patient’s anxiety and sedation were
assessed using a numerical rating scale (NRS) before taking medication and at
10, 30, 60, and 90 minutes after. Psychomotor function also was assessed upon
arrival in the operating room and 30 and 90 minutes after tracheal extubation.
The Pasipay group experienced significantly lower mean NRS scores over time (P
< 0.001) with no other significant differences between groups. This
suggests that oral administration of passionflower prior to surgery can reduce
anxiety without inducing sedation.47
In
2001, a randomized, double-blind, controlled study compared the efficacy of
passionflower to the conventional pharmaceutical sedative drug oxazepam in
treating generalized anxiety disorder (GAD). Outpatients diagnosed with GAD (N
= 36) at least six months prior to the study were randomly assigned to receive
either 45 drops/day of Pasipay plus a placebo tablet or 30 mg/day oxazepam plus
placebo drops for four weeks. Both Pasipay and oxazepam were effective in
treating GAD, and while there were no significant differences between the two
groups regarding total side effects, patients on oxazepam experienced
significantly more problems related to impairment of job performance.48
One
double-blind, placebo-controlled, repeated-measures study published in 2011
investigated the effects of passionflower tea on sleep. Healthy volunteers (N =
41) were recruited and provided information regarding their health and sleeping
patterns. All had mild sleep difficulties and were not taking any medications
or remedies other than contraception. Passionflower tea bags (2 g of dried P. incarnata leaves, stems, seeds, and flowers; Hilde Hemmes’ Herbal
Supplies Pty. Ltd.; Ridgehaven, South Australia) or parsley tea bags (2 g of Petroselinum crispum [Apiaceae]; same producer) were provided with brewing
instructions. Each participant drank one tea or the other each night for a week
while keeping a sleep diary (which included a subjective report of their sleep,
as well as the number and duration of naps, types and amounts of caffeine and
alcohol consumption, and bedtime). Participants also completed the STAI
questionnaire on the seventh morning. After a one-week washout period,
participants switched to the other tea and repeated the process for another
week. Additionally, 10 volunteers participated in overnight polysomnography
(PSG) on the last night of each treatment period, the results of which were
used to validate sleep diaries. Of the PSG and subjective sleep parameters
analyzed, subjective sleep quality alone was significantly better in the passionflower
group than in the placebo group. The authors opined that the small sample size
limited the power of the statistical analysis. Furthermore, they stated that
the passionflower tea dose was three times less than the recommended dosage and
questioned if tea might not be the most effective way of administering
passionflower. They also suggested that using volunteers with mild sleep issues
rather than clinically diagnosed insomnia left little room for improvement and
that their study may have been too short to observe significant improvement.49
Based
on the German Commission E’s approval of passionflower for nervous restlessness
and the British Herbal Compendium’s indication of passionflower
for ADHD, researchers in 2003 conducted an eight-week, randomized, parallel
group study on 34 children diagnosed with ADHD. One group was administered
Pasipay (0.04 mg/kg/day, twice daily) and the other methylphenidate (1
mg/kg/day, twice daily). Patients were assessed by a child psychiatrist at
baseline, 14, 28, 42, and 56 days. There were no significant differences
between the two groups at baseline or during the course of the study, and both
groups showed significant improvement over eight weeks of treatment. The
methylphenidate group did experience more probable side effects than the
Pasipay group, including decreased appetite (seven subjects vs. two subjects,
respectively) and anxiety/nervousness (six subjects vs. no subjects,
respectively). The authors suggest that passionflower may be an appropriate
treatment for ADHD, especially in children who do not tolerate pharmaceutical
stimulants, but that larger studies are needed to confirm their findings.50
One
RDBPC study from 2001 investigated the efficacy of passionflower as an adjuvant
to help with anxiety and insomnia during detoxification from opioids using
clonidine. Male opioid addicts (N = 65) were randomly assigned to receive
either 0.8 mg/day of clonidine plus 60 drops of “passiflora extract” (no further information provided) or 0.8 mg/day of
clonidine plus 60 drops of placebo, three times per day in divided doses.
Severity of opioid withdrawal syndrome was measured on days 0, 1, 2, 3, 4, 7,
and 14 using the Short Opiate Withdrawal Scale (SOWS). Both groups experienced
significant alleviation of physical withdrawal symptoms, but the
passiflora-clonidine group experienced a significant reduction in mental
symptoms starting on day 2, which was not the case in the clonidine-only group.
The authors suggest that passiflora may indeed be an effective adjuvant in the
management of opioid withdrawal but that further, larger studies are needed to
confirm these results.51
As
mentioned previously, passionflower is most often used in combination with
other herbs, and there have been studies that have investigated the efficacy of
these combinations. In a randomized, controlled trial published in 2013, NSF-3
(410 mg of polyherbal extract containing 80 mg of passionflower, 300 mg of
valerian [Valeriana officinalis,
Caprifoliaceae], and 30 mg of hops [Humulus lupulus, Cannabaceae]; M/s
Tablets India; Chennai, India) performed as well as the conventional
pharmaceutical sedative zolpidem in improving total sleep time, sleep latency,
and insomnia index scores, and decreasing number of nightly awakenings.52
An
Italian study published in 2011 showed that children taking 0.5 mL/kg body
weight of Vagostabil Junior (containing California poppy [Eschscholzia californica, Papaveraceae] aerial parts dry extract titrated to
0.8% total alkaloids expressed as protopine, and passionflower aerial parts dry
extract titrated at 4% minimum total flavonoids expressed as vitexin;
Cristalfarma; Milan, Italy) had significantly improved sleep quality without
adverse effects over the course of 14 days.53
FUTURE OUTLOOK
There are no known
comprehensive reports available on the conservation status of wild P. incarnata in its native southeastern United States habitat. However, the passionflower vine thrives in
human-disturbed areas, and its geographical distribution has expanded over
time. In some places where it has been introduced outside of its native
habitat, the species is considered invasive.8 Even within its
geographical origin, the vines spread from its natural areas along edges of
forested areas into agricultural fields, pastures, and citrus groves.5
According to Lockard and Swanson (1998), “Many farmers find this plant to be a
nuisance and might very well accept your offers to harvest it.”54
For sustainable wild-collection, Lockard and Swanson recommend that harvesters
should not disturb the roots, leave at least 10% of a passionflower vine patch
unharvested in order to facilitate regeneration, and rotate patches rather than
returning to the same patch year after year. Harvesting should be carried out “on
sunny days, late in the morning after the dew has dried.”54
In recent decades,
some herbal product companies have switched from wild-collected passionflower
herb to material produced under controlled cultivation. One reason for this
switch is that passionflower vines are climbers that attach to, and get tangled
up with, other plants, particularly with other climbing vines. This can make it
difficult for harvesters to completely separate out passionflower aerial parts
and avoid unintentional adulteration with plant parts of non-target species.54
Furthermore, highly invasive Asian climbing vines, including kudzu (Pueraria montana
var. lobata, Fabaceae) and precatory (Abrus precatorius, Fabaceae), now
share habitat with P.
incarnata vines in the southeastern US. Both kudzu and precatory are
listed as noxious weeds in Category I of the Florida Exotic Pest Plant Council
(FLEPPC) list of invasive plant species. Category I species are defined as “invasive
exotics that are altering native plant communities by displacing native species,
changing community structures or ecological functions, or hybridizing with
natives.”55 Toxic precatory vine plant parts have been implicated in
the past as potential adulterants to various wild-harvested materials.56
And for passionflower cultivated outside its native habitat, potential
contamination with pyrrolizidine alkaloid (PA)-containing weeds (particularly
in Europe) was identified in a May 2016 public statement by the EMA. The EMA
listed “Passiflorae herba” among the top 10 herbal ingredients most likely affected by PA contamination and therefore made recommendations for risk management and quality control,
including that farms should implement “significantly enhanced” good
agricultural and collection practices (GACPs) to mitigate the risk.57
Although in recent
years there have been occasional market shortages of certified organic
passionflower of pharmacopeial quality, there is evidence that passionflower
production is occurring increasingly through sustainable agricultural
practices, along with very recently enhanced GACPs to avoid contamination with
non-target weed species. Presently, the main source countries for certified
organic cultivated passionflower are France and Italy, but organic cultivation
is also increasing in the United States, especially at farms in Kentucky,
Missouri, North Carolina, and California. Given that P. incarnata is not an
endangered or threatened species in its native habitat (although potentially
competing with highly invasive climbing vines), and that controlled cultivation
is also increasing, it appears that increased global demand can be satisfied
through sustainable production methods.
The use of
passionflower herb (or extracts thereof) as an active ingredient of traditional
herbal medicines, modern phytomedicines, and herbal dietary supplements is
likely to continue to increase globally, as are sustainable production systems,
whether through controlled cultivation or wild-harvesting. Some experts,
however, have cautioned that care must be taken by companies to identify and
select specific chemotypes in order to ensure reproducible quality and
efficacy.39
–Gayle Engels and
Josef Brinckmann
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