Issue:
118
Page: 41
Exploratory Study Associates Rhodiola with Reduction in Burnout and Stress Symptoms
by Kathleen Bennett
HerbalGram.
2018; American Botanical Council
Reviewed: Kasper S, Dienel A. Multicenter,
open-label, exploratory clinical trial with Rhodiola rosea extract
in patients suffering from burnout symptoms. Neuropsychiatr Dis Treat.
2017;13:889-898. doi: 10.2147/NDT.S120113.
“Burnout” refers to stress-related
emotional and physical exhaustion and is associated with a decrease in
performance. Symptoms can be physically and mentally debilitating, and there is
a considerable risk of developing psychiatric and somatic disorders (e.g.,
depression, anxiety, and cardiovascular conditions). Conventional medications
for these disorders, such as antidepressants and anxiolytics, may result in
unpleasant side effects, so researchers are looking for alternative treatment
options. Traditionally used as an adaptogen to manage symptoms of anxiety,
depression, stress, and associated fatigue, rhodiola (Rhodiola rosea,
Crassulaceae) root and rhizome preparations previously have demonstrated therapeutic
potential for relieving symptoms of burnout.1
This exploratory, open-label,
single-arm, multicenter study investigated the effects of rhodiola on patients
(N = 117) aged 30-60 years with comparable stress burdens (e.g., home caring of
family members with disabilities) and who exhibited burnout symptoms. The study
was conducted at four locations in Vienna, Austria, and took place from July
2011 through October 2012.
The experimental rhodiola preparation
was a 200-mg tablet of Vitango (also known as Vitano; Dr. Willmar Schwabe
GmbH & Co. KG; Karlsruhe, Germany) taken twice daily, before breakfast and
lunch, for a treatment duration of 12 weeks. The active ingredient of Vitango
is WS 1375 (also known as Rosalin; Dr. Willmar Schwabe GmbH & Co. KG),
a proprietary dry ethanolic extract (60% w/w) of R. rosea roots
(1.5-5:1), corresponding to 300-1,000 mg of rhodiola root.2
The severity of symptoms of stress and
burnout, mood state, and physical function were assessed at the screening visit
prior to treatment and at week 12 through a combination of validated
questionnaires (self-reported), clinician assessments, physical examinations
(including vital signs), laboratory tests (not described), and an
electrocardiogram (ECG). Along with the other measures, seven subjective stress
symptoms were evaluated in patients four times during the trial using Numerical
Analog Scales (NASs). The results showed a significant improvement beginning on
day 7 of treatment and improvement continued until week 12, with a decrease in
mean overall scores for all seven NAS measures.
In addition, each patient was assessed
by a clinician at the beginning of the trial, on day 7, week 8, and the end of
the trial using the Clinical Global Impression (CGI) scale to evaluate the
severity of burnout and stress symptoms and their change from baseline. The CGI
scores showed a marked improvement by week 12 in 41.9% of patients.
The authors concluded that treatment
with rhodiola extract improved most outcome measures of life-stress and burnout
symptoms, but their findings remain preliminary and should be confirmed in
randomized controlled trials.
—Kathleen
Bennett, MS
References
- Brown
RP, Gerbarg PL, Ramazanov Z. Rhodiola rosea: A phytomedicinal
overview. HerbalGram. 2002;(56):40-52.
- Vitano
Rhodiola Rosea Product Monograph. Dr. Willmar Schwabe Pharmaceuticals website.
Available at:
www.schwabepharma.co.uk/wp-content/uploads/2015/06/Vitano-Monograph-PRINT.pdf.
Accessed April 16, 2018.
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