Re: Review Reveals Therapeutic Indications for Rose Hip
Chrubasik C, Roufogalis BD, Müller-Ladner U, Chrubasik S. A systematic review on the Rosa canina effect and efficacy profiles. Phytother Res. 2008;22: 725-733.
In 1990, the German Commission E published three monographs
on the traditional use of two parts from species of the genus Rosa L.: rose hip (Rosae pseudofructus sine fructus; the
ripe, fresh, or dried seed receptacle of various species, freed from seed and
attached trichomas); rose hip and seed (Rosae
pseudofructuscum fructibus; the ripe, fresh or
dried pseudofruits, including the seed); and rose hip seed (Rosae fructus; the ripe, dried seed).1
Because "the evidence for some of the health claims attributed to the rose
hip parts was not sufficiently documented and for others not documented at all,
therapeutic indication was not recommended by the Commission E for any of the
plant parts or preparations thereof," say these authors. The authors
conducted a comprehensive review of the literature to summarize the
pharmacological and clinical effects of Rosa canina (dog rose) to reevaluate its effectiveness in traditional
medicine.
The authors performed computerized literature searches of
Ovid, PubMed, and the Cochrane Collaboration Library back to 1985 to identify
studies with R. canina rose hip. They also hand-searched their own files
and the bibliographies of all located papers.
Cited in their review are a number of in vivo and in vitro
studies demonstrating high antioxidative activities of various preparations and
isolated constituents from rose hip. Although the phenolic fraction contributed
to the antioxidant activity, the lipophilic component was the most effective
when study results were compared based on the relation between total
antioxidant capacity and the content of antioxidants, say the authors.
Cited studies demonstrating the anti-inflammatory activity
of several fractions of the ethanol extract of the rose hip and seed suggest
that the lipophilic component contributes to the anti-inflammatory principle.
An 80% acetone extract for rose hip and seed (50 mg/kg) or
seed (12.5 and 25 mg/kg) was found to show substantial inhibitory effect on the
gain of body weight and/or weight of visceral fat without affecting food intake
in mice for two weeks after administration of the extracts and with no obvious
toxic effect.2 However, extracts from the rose hip (pericarp or
shell) given at 100 and 200 mg/kg/day did not show such an effect. The main
constituent trans-tiliroside was identified to inhibit dose-dependent body
weight gain and visceral fat weight at a dose of 0.1-10.0 mg/kg daily.
In rats, plasma cholesterol and triglyceride concentrations
were significantly lower after a rose hip oil diet than in control animals, but
high density lipoprotein ("good") cholesterol was also lower.
Other in vivo and in vitro studies cited by the authors
demonstrate prevention of ethanol-induced ulcers by rose hip seed aqueous
extract; no significant blood glucose lowering effect of aqueous and ethanol
extracts of dried rose hip and seed; varied results of rose hip seed on muscle
tone and nerve conduction; a significant cytotoxic effect of ethanol and
petroleum ether extracts of dried rose hip seed; and a weak antibacterial
effect of a methanol extract of rose hip seed against Escherichia
coli.
The authors cite six clinical studies, four of which were
carried out with a rose hip and seed powder Litozin® [Hyben Vital
International; Langeland, Denmark] from the subspecies lito. "Although evidence of the
effectiveness is only moderate for osteoarthritis (two exploratory clinical
studies of good quality) and poor for rheumatoid arthritis and chronic low back
pain (one exploratory study for each indication), there is no doubt of the
overall anti-inflammatory and analgesic potential of Litozin®," they
write.
A rose hip preparation was investigated in a randomized
double-blind study including 60 patients suffering from irritable bowel
syndrome. Patients receiving the proprietary rose hip drink as placebo profited
less than those receiving additional Lactobacillus
plantarum 9843, but abdominal pain was reduced in both groups.3
The authors recommend future research using Litozin as part
of a hypocaloric diet in light of rose hip's probiotic, stool regulating, and
muscle relaxant effects and rose hip seed's lipid-lowering, antiobesity, and
antiulcerogenic effects.
―Shari Henson
References
1Blumenthal M, Busse WR, Goldberg A, Gruenwald J, Hall
T, Riggins CW, Rister RS, eds. Klein S, Rister RS, trans. The Complete German Commission E
Monographs―Therapeutic Guide to Herbal Medicines.Austin, TX: American
Botanical Council; Boston:
Integrative Medicine Communication; 1998:368-369.
2Ninomiya K, Matsuda H, Kubo M, Morikawa T, Nishida N,
Yoshikawa M. Potent anti-obese principle from Rosa canina: structural requirements and mode of action of
trans-tiliroside. Bioorg Med Chem Lett.
2007;17:3059-3064.
3Nobaek
S, Johansson ML, Molin G, Ahrne S, Jeppsson B. Alteration of intestinal
microflora is associated with reduction in abdominal bloating and pain in
patients with irritable bowel syndrome. Am
J Gastroenterol. 2000;95:1231-1238.