Re: Clinical Study Concludes That an Aloe Cream Can Be a Safe Treatment for Mild to Moderate Chronic Plaque Psoriasis
Choonhakarn C, Busaracome P, Sripanidkulchai B, Sarakarn P. A prospective, randomized clinical trial comparing topical aloe vera with 0.1% triamcinolone acetonide in mild to moderate plaque psoriasis. A prospective, randomized clinical trial comparing topical aloe vera with 0.1% triamcinolone acetonide in mild to moderate plaque psoriasis. 2010 Feb 1;24(2): 168-172.
Aloe (Aloe vera) gel has anti-inflammatory and
wound-healing properties. Clinical research has provided mixed evidence
regarding the efficacy of aloe preparations in the treatment of psoriasis.1,2
In this double-blind, randomized clinical trial, researchers compared the
efficacy of topical aloewith 0.1%
triamcinolone acetonide (TA) in the treatment of mild to moderate plaque
psoriasis.
The study
was conducted between October 2006 and September 2007. The researchers
recruited patients with chronic plaque psoriasis from the Division of Dermatology
at SrinagarindHospital
at KhonKaenUniversity in Khon Kaen, Thailand.
The patients were 18 years or older and had clinically diagnosed psoriasis
covering more than 10% of the body surface. During a 4-week wash-out period, the
patients did not use topical or systemic psoriasis treatments. The patients were
randomized using a simple random number table to receive either an aloe cream
containing 70% aloe mucilage (n=37) or the 0.1% TA cream (n=38). Both creams
were prepared by the Faculty of Pharmaceutical Sciences at KhonKaenUniversity (Khon
Kaen, Thailand).
The patients applied the creams twice daily for 8 weeks. The researchers
measured the severity of disease on a scale of 0-72 with the Psoriasis Area Severity
Index (PASI). The change in PASI scores after 8 weeks of treatment was the
primary outcome measure. The researchers considered a reduction of 75% or more
a "marked" response, a reduction of 50-74% a "moderate"
response, and a reduction of less than 50% a "slight" response. The
patients completed the Dermatology Life Quality Index (DLQI) to measure their
quality of life.
There were
80 patients at baseline, and 3 in the aloe group and 2 in the TA group were
lost to follow-up. There were no significant differences between the groups in baseline
DLQI or PASI scores. None of the patients experienced a complete recovery after
8 weeks of treatment. In the aloe group, 6 patients (16.2%) experienced a
marked response, while 4 patients (10.5%) in the TA group did so. In the aloe
group, 20 patients (54.1%) experienced a moderate response to treatment, while
25 patients (65.8%) in the TA group had a moderate response. The researchers
found that 10 patients (27%) in the aloe group and 9 patients (23.7%) in the TA
group had a slight response to treatment. In the aloe group, 1 patient showed
no response to treatment. After 8 weeks, the average change in PASI scores was significantly
greater in the aloe group, when compared to the TA group (P=0.0237); however,
the average PASI scores were not significantly different between the groups.
There were no statistically significant changes in DLQI scores after 8 weeks of
treatment, although both groups experienced decreases. The authors report that
no serious adverse events occurred during the study, but 6 patients in the aloe
group experienced stinging and itching at the plaques during the first week.
The authors
propose that aloe's anti-inflammatory effects may be responsible for the
effects observed in this study. They conclude that aloe cream "can be
considered a safe, alternative treatment for mild to moderate chronic plaque
psoriasis." More research is needed to confirm the results of this
study.
—Marissa Oppel-Sutter, MS
References
1.Syed TA,
Ahmad SA, Holt AH, et al. Management of psoriasis with Aloe vera extract in a hydrophilic cream: a placebo-controlled,
double-blind study. Trop Med Int Health.
Aug 1996;1(4):505-509.
2.Paulsen
E, Korsholm L, Brandrup F. A double-blind, placebo-controlled study of a
commercial Aloe vera gel in the
treatment of slight to moderate psoriasis vulgaris. J Eur Acad Dermatol Venereol. May 2005;19(3):326-331.