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- Olive (Olea europaea, Oleaceae) Oil
- Burn Wound Healing
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Date:
05-29-2015 | HC# 121432-521
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Re: Olive Oil Consumption Accelerates Wound Healing in Patients with Burns
Najmi
M, Vahdat Shariatpanahi Z, Tolouei M, Amiri Z. Effect of oral olive oil on
healing of 10-20% total body surface area burn wounds in hospitalized patients.
Burns. May 2015;41(3):493-496.
Nutritional
support is important in the treatment of thermally injured patients. Glucose,
lipids, and fat composition are all important for wound healing and improving
the immune response of severely burned patients. Some animal studies have shown positive effects of oleic acid on
wound healing.1,2 Noting that there have been no studies showing the
effects of oral olive (Olea europaea,
Oleaceae) oil on burn wound healing, the authors report on their randomized,
controlled study of hospitalized patients with burns covering 10-20% of total
body surface area to evaluate these effects.
Conducted
from September 2012 to December 2013, the study enrolled 104 patients (mean
age, 33.34 ± 7 years) with deep second-degree burn wounds. Of those 104
patients, 100 completed the study (50 in the study group and 50 in the control
group). Two patients in the study group discontinued the study because of
intolerance to olive oil odor and 2 in the control group because of early
discharge from the hospital. Baseline characteristics were similar for all
patients.
All
patients received similar wound care treatment (wound excision, skin grafting,
and antibiotic therapy) and pain management with intravenous morphine. Within
24 hours of hospital admission, the patients were started on oral nutrition,
with macronutrient composition set at 20% protein, 60% carbohydrates, and 20%
lipids. For the study group, olive oil was used as the oil in the diet; for
those in the control group, sunflower (Helianthus
annuus, Asteraceae) oil was used. Additional olive oil or sunflower oil was
added to salads to ensure a 20% total fat content.
All
patients continued on the diet until they were discharged from the hospital
with complete healing of burn wounds and donor sites. While hospitalized, they
were examined for wound infection, sepsis, and healing of grafted and
nongrafted wounds. Complete graft healing was defined as graft-take of more
than 90% of the graft size.
No
significant differences in serum albumin levels or total calorie intake were
observed during the study between the 2 groups. The percentage of grafting
candidates was not significantly different between the groups; 52.8% were in
the control group and 50% were in the olive oil group. No evidence of graft
rejection, wound infection, or sepsis was observed in any of the patients. Two
patients in the control group were admitted to the intensive care unit (ICU)
during therapy; however, no significant difference in ICU admission was evident
between the groups.
The
mean duration of wound healing was 7.2 ± 0.5 days in the olive oil group
compared with 8.7 ± 0.5 days in the control group (P=0.04). The mean number of
days spent in the hospital was 7.4 ± 0.5 in the olive oil group compared with
8.9 ± 0.4 in the control group (P=0.05).
Citing
earlier studies, the authors suggest that the antioxidant and anti-inflammatory
components of olive oil, such as hydrocarbons, polyphenols, tocopherols,
sterols, and triterpenoids,3,4 may be responsible for minimizing
injury in patients with burns. In an earlier animal study, the effects of olive
oil on immune function were attributed to oleic acid rather than trace elements
or antioxidants.3 Other studies in rats have shown accelerated wound
healing with either oral or topical olive oil use by modulation of
inflammation.
The
authors conclude that "an oral diet provided with olive oil in patients
with burn may accelerate wound healing and decrease the duration of
hospitalization." Studies of larger numbers of patients with burns of more
than 20% total body surface area who consume greater doses of olive oil may yield
more significant effects, say the authors.
—Shari Henson
References
1Cardoso CR, Favoreto S
Jr, Oliveira LL, et al. Oleic acid modulation of the immune response in wound
healing: a new approach for skin repair. Immunobiology.
2011;216(3):409-415.
2Rodrigues HG, Vinolo
MA, Magdalon J, et al. Oral administration of oleic or linoleic acid
accelerates the inflammatory phase of wound healing. J Invest Dermatol. 2012;132(1):208-215.
3Perona JS,
Cabello-Moruno R, Ruiz-Gutierrez V. The role of virgin olive oil components in
the modulation of endothelial function. J
Nutr Biochem. 2006;17(7):429-445.
4Puertollano MA,
Puertollano E, Álvarez de Cienfuegos G, de Pablo MA. Significance of olive oil
in the host immune resistance to infection. Br
J Nutr. 2007;98(Suppl 1):S54-S58.
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