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- Lavender (Lavandula angustifolia, Lamiaceae)
- Sleep Quality
- Aromatherapy
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Date:
02-15-2016 | HC# 081553-538
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Re: Lavender Aromatherapy Improves Sleep Quality in College Students
Lillehei
AS, Halcón LL, Savik K, Reis R. Effect of inhaled lavender and sleep hygiene on
self-reported sleep issues: A randomized controlled trial. J Altern Complement Med. 2015;21(7):430-438.
Sleep
problems are associated with numerous health concerns such as anxiety, depression,
cardiovascular disease, hypertension, inflammation, obesity, impaired glucose tolerance,
and diabetes. Essential oils, such as lavender (Lavandula angustifolia, Lamiaceae) flower, which
have sedative or hypnotic properties, have been evaluated for sleep therapy. The
purpose of this randomized, double-blind, placebo-controlled study was to
evaluate the effect of inhaled lavender essential oil on sleep quality and
quantity in college students.
Students (n = 79,
aged 18-36 years) with self-reported sleep issues (difficulty falling asleep,
frequent awakenings during the night, or daytime sleepiness) were recruited
from the University of Minnesota, Minneapolis, Minnesota, campus. Students were
excluded if they were pregnant, working a night shift, or used prescription
sleep medication. All subjects received sleep hygiene information based on the
National Institutes of Health (NIH) recommendations—specifically, (1) maintain
a regular sleep schedule; (2) avoid fluid intake before bed and food, caffeine,
alcohol, and nicotine late in the day; (3) create a good sleeping environment
(e.g., wear ear plugs and a sleep mask, and avoid screens and texting); (4)
create a relaxing bedtime routine; (5) keep up with school work; and (6)
exercise regularly.
Each 3-cm adhesive patch
contained a 1-cm disc of absorbent material impregnated with 55 µL lavender oil
(supplied by Wyndmere Naturals, Inc.; Minnetonka, Minnesota) or left blank
(placebo). Based on the gas chromatography-mass spectrometry (GC-MS) analysis
provided to the principal investigator, "the essential oil used was chemically consistent with the International
Organization for Standardization (ISO) for L.
angustifolia." The
patch (supplied by Bioesse Technologies, LLC;
Minnetonka, Minnesota)
had a skin-barrier backing to prevent skin absorption of the essential oil and a
time-release function to last 6-8 hours. For 5 consecutive nights, subjects applied
a patch on their mid-upper chest at bedtime and removed it in the morning.
Sleep
quantity was measured via a Fitbit® tracker (to measure movement
during sleep) and sleep diary, and sleep quality was measured with the
Pittsburgh Sleep Quality Index (PSQI) and the NIH Patient-Reported Outcomes
Measurement Information System (PROMIS) sleep disturbance short form. Subjects
also completed a sleep hygiene survey (SHS). Assessments were made at baseline,
at day 5, and 2 weeks after the completion of treatment.
The
majority of the subjects were white (67%) and female (69%); both treatment
groups had similar demographics. There were technical issues with the Fitbit,
resulting in unacceptable levels of missing data (only 14% of the data were
recovered). The patches were reported to have fallen off during sleep in 37% of
the person nights (n = 146); however, the data analysis indicated that the patch
falling off was not a significant covariate. Based on SHS scores, sleep hygiene
was better during the 5-day treatment phase compared to baseline and
post-treatment in both groups; there were no significant differences in SHS
scores between groups at any time point. Based on the PSQI, both groups had
poor sleep before the intervention, and there was no difference between groups
at baseline.
Post-treatment,
sleep quantity did not significantly differ between groups; both groups had a
significant decrease in awakenings (P = 0.02) and increase in being able to
fall asleep easily (P = 0.001).
The
PSQI and PROMIS assessments indicated that sleep quality was significantly
better for the lavender group compared with the sleep hygiene-only group at day
5 (P = 0.01 and P = 0.04, respectively) and at follow-up (P ≤ 0.001 and P =
0.007, respectively). Better sleep hygiene was also associated with better
sleep quality but to a much lesser degree at day 5 (P = 0.02 and P = 0.03,
respectively) and at follow-up (P = 0.03, PROMIS only). The lavender group had
a clinically significant improvement in sleep quality, while there was no
clinically significant change in sleep quality in the sleep hygiene-only group.
The lavender group had less daytime fatigue at day 5 and follow-up (P = 0.02
and P = 0.009, respectively) and was more likely to wake refreshed at day 5 (P =
0.01). The 4 adverse event reports (minor skin irritation, each lasting 1 night)
were attributed to the patch adhesive.
The authors conclude
that, in college students with self-reported sleep issues, lavender essential
oil inhalation improved sleep quality, and the effect persisted for 2 weeks after
lavender aromatherapy was suspended. "The persistent effect of lavender on sleep quality at two-week follow-up
suggests a re-balancing or long-acting effect on the sleep cycle, although the
exact mechanism of action is unknown." The limitations of the study were the lack
of statistical power to evaluate potential differences due to race or
ethnicity, the loss of objective Fitbit data regarding sleep quantity, the
subjective self-reporting nature of the data, the lack of standardized dosages
due to the poor patch adherence, and the potential failure of subject blinding
due to the lavender scent. The authors conclude that this trial "supports the use of lavender and sleep hygiene as safe, accessible, and effective
interventions for self-reported sleep issues in college students. Further
research to study their effect on other populations and additional studies
exploring the duration of intervention effects are needed."
—Heather S. Oliff,
PhD
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