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- Tongkat Ali (Eurycoma longifolia, Simaroubaceae)
- Erectile Dysfunction
- Systematic Review/Meta-analysis
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Date:
05-13-2016 | HC# 111564-544
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Re: Systematic Review/Meta-analysis of Clinical Efficacy of Tongkat Ali for Erectile Dysfunction
Kotirum S, Ismail SB, Chaiyakunapruk N. Efficacy of Tongkat Ali (Eurycoma longifolia) on erectile function improvement: systematic
review and meta-analysis of randomized controlled trials. Complement Ther Med. October 2015;23(5):693-698.
Erectile dysfunction (ED) is
defined as the inability of a man to attain and/or maintain an erection sufficiently
for sexual activity. ED can negatively impact the quality of life of many men
throughout the world. Also, due to varying cultural norms, patients may not
seek conventional medical help. Tongkat Ali (Eurycoma longifolia, Simaroubaceae) has been used traditionally in
Malaysia to boost energy and as an aphrodisiac. It has been noted to contain
several bioactive compounds, such as polyphenols, alkaloids, and notably the
quassinoid eurycomanone. One study recently suggested the water extract of the
roots can improve ED, but the underlying mechanism remains unknown. This
systematic review and meta-analysis sought to compile the evidence on the
efficacy of Tongkat Ali root water extract for ED in men.
The authors searched the databases
MEDLINE, EMBASE, Cochrane Central Register of Controlled Trials,
ClinicalTrials.gov, and the Allied and Complementary Medicine Database from as
early as possible to October 10, 2014. The terms "Tongkat Ali,"
"Eurycoma longifolia
(Jack)," and "pasak bumi" were used in the search. Studies were
included if they were randomized, controlled, clinical trials and tested
Tongkat Ali in patients with ED. Duplicate studies or those that showed a lack
of reporting were excluded.
Study quality was determined by
use of the Cochrane risk of bias system and the Jadad scale. Information used
from the study included patient number and characteristics, dosage and form of
Tongkat Ali, duration, and outcomes. Results of the International Index of
Erectile Function (IIEF-5) symptom questionnaire were considered the main
outcome. This score rates sexual performance and satisfaction according to five
questions that are rated from low (1) to high (5).
From a total of 342 articles, the
authors found two randomized, placebo-controlled studies with a total of 139
patients. Patients were otherwise healthy, heterosexual men in the United
States, ranging in age from 40-65 years old, and married Malaysian men from
30-55 years old. At baseline, the IIEF-5 scores were 12.36-15.77 and
21.30-22.29 (less than 21 indicates ED), and scores were compared after six and
12 weeks. The freeze-dried root water extract of Tongkat Ali at dosages of 200
mg daily along with 100 mg of small water pepper (Persicaria minor syn. Polygonum
minus, Polygonaceae) and 300 mg daily of Tongkat Ali alone were used in
both studies. [Note: Source of plants, preparation of small water pepper, and ingredients
of placebo were not mentioned.]
It was determined that both
studies had a high risk of bias due to selective reporting of endpoints. Also,
baseline discrepancies of IIEF-5 scores between groups in one study contributed
to high risk of bias. The Jadad scores for the two studies were 5 and 4,
indicative of high study quality. The weighted mean difference (WMD) of IIEF-5
was not significantly different at weeks six and 12 as compared to the placebo;
significant heterogeneity of the data at both timepoints was observed (P=0.003
and <0.001, respectively).
Due to variation of the IIEF-5
scores at baseline between groups in one of the studies, score changes from
baseline to weeks six and 12 were analyzed. The change in score was found to
decrease from baseline to six weeks in the Tongkat Ali group, suggesting no ED
improvement. The change in score from baseline to 12 weeks was 0.91 but was
significantly heterogeneous (P=0.002), possibly due to baseline discrepancies
in score. The authors observed that patients with lower initial IIEF-5 scores
experienced score improvement with Tongkat Ali consumption, while those with
higher scores did not see any effect. Adverse side effects were not
significantly different between groups; no serious adverse side effects
associated with the treatment were reported.
This meta-analysis, which reviewed two clinical studies, suggests
that Tongkat Ali may be efficacious for treating ED in men with low IIEF-5
scores, but further studies are certainly needed to make a better conclusion. Potential
confounding factors include the use of another botanical in combination with
Tongkat Ali, differential degrees of ED among patients, and very small sample
size of trials. The
two studies used Physta® Tongkat Ali extract (Biotropics Malaysia
Berhad; Shah Alam, Selangor, Malaysia) which is standardized to 0.8-1.5% eurycomanone,
>30% polysaccharide, >22% protein, and >40% glycosaponin.
One
of the authors (SB Ismail) of this review is one of the authors of an article included
in the review, but had no role in the screening and selecting of eligible
studies.
—Amy C. Keller, PhD
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