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- Green Tea (Camellia sinensis, Theaceae)
- Cholesterol
- Weight
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Date:
03-15-2018 | HC# 081763-588
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Re: Clinical Trial Shows Consuming Green Tea Powder May Lower Low-density Lipoprotein Cholesterol
Igarashi
Y, Obara T, Ishikuro M, et al. Randomized controlled trial of the effects of
consumption of 'Yabukita' or 'Benifuuki' encapsulated tea-powder on low-density
lipoprotein cholesterol level and body weight. Food Nutr Res. June 19, 2017;61(1):1334484. doi: 10.1080/16546628.2017.1334484.
Green tea (Camellia
sinensis, Theaceae) is consumed worldwide and associated with multiple health
benefits, including a decreased risk of cardiovascular disease (CVD). Many
bioactive compounds have been reported from green tea and may explain the
observed effects. One widely acknowledged risk factor for CVD is hyperlipidemia,
including elevated low-density lipoprotein (LDL) cholesterol. Consumption of
catechins, compounds found in tea, has been reported to result in a lowering of
LDL cholesterol. This double-blind, randomized, placebo-controlled clinical
trial investigated whether 2 different types of green tea would impact LDL
cholesterol concentrations along with body weight.
This study, conducted at the Tokuiku Health
Promotion Center and the Daitou Health Promotion Center in Kakegawa, Japan,
between September 2009 and December 2009, incorporated subjects (both men and
women) aged 30-70 years old with body mass index >23 kg/m2. Other
inclusion criteria were total cholesterol >200 mg/dl and LDL cholesterol >120
mg/dl. Those using drugs to treat dyslipidemia, hypertension, or diabetes, and
those with pre-existing heart problems, food or drug allergies, or who were
pregnant or lactating were excluded. Included study subjects (n=151) were randomly
assigned to receive Yabukita green tea (n=51) or Benifuuki green tea (n=49) powder
in capsules (180 mg of powder) or placebo (n=51) capsules containing 180 mg of
starch. Subjects took 10 capsules per day for a total daily dosage of 1.8 g per
day for 12 weeks. No mention is made about the source or processing of green
tea powder. [Note: Although not mentioned in the text, it is assumed that
Yabukita and Benifuuki are cultivars.]
Subjects refrained from consuming drinks
containing catechin compounds 2 weeks before the study started, and primary
outcomes were LDL cholesterol and body weight. Secondary outcomes included
additional lipid concentrations, fasting glucose and glycosylated hemoglobin,
high-sensitivity C-reactive protein (hs-CRP), and 8-hydroxy-2'-deoxyguanosine
(8-OHdG, a marker of oxidative stress). At baseline, there were no significant
differences in any of the parameters; however, hs-CRP and insulin were
different among groups, approaching significance (P=0.09 and 0.08,
respectively).
There were no adverse side effects at the study's
end. Subjects in both the Yabukita green tea and Benifuuki green tea groups had
significant decreases in LDL cholesterol from baseline to endpoint (149.5 ±
26.2 mg/dl vs. 138.8 ± 27.6 mg/dl, P=0.001 and 146.3 ± 29.1 mg/dl vs. 138.2 ±
27.6 mg/dl, P=0.001, respectively). The changes in LDL cholesterol seen in the
green tea groups were significantly different from those of the placebo group
(P<0.05 for both). Subjects in the placebo group had a significant increase
in body weight from baseline to endpoint (P=0.002); however, no effect on body
weight was observed in those consuming green tea.
Only the Yabukita green tea group had a
significant decrease in waist circumference (P=0.006); significant differences
in the change in this parameter were observed between the 2 tea groups (P=0.03,
the Benifuuki group had an increase in waist circumference) and between the
Yabukita green tea group and placebo (P=0.02, the change in weight decline was
greater in the Yabukita group). Those in both the placebo and Benifuuki green
tea groups had significant increases in high-density lipoprotein (HDL)
cholesterol concentrations. Significant differences in the amount of increase
were seen between Benifuuki and placebo (P=0.03, HDL cholesterol of those in
the Benifuuki group increased to a greater degree) and between the 2 green tea
types (P=0.02, HDL cholesterol in the Yabukita group decreased). 8-OHdG
concentrations were significantly decreased in all groups at the end of the
study (P<0.05 for all). Insulin was significantly increased and hs-CRP was
significantly decreased only in those consuming the Benifuuki green tea (P=0.03
and 0.01, respectively). The rate of 8-OHdG generation was significantly
decreased in both the placebo group and the group consuming Yabukita green tea
(P=0.02 for both).
This study suggests that consuming green tea powder
may lower human blood LDL cholesterol, and that different cultivars may benefit
different health outcomes. The authors mention that the results with LDL
cholesterol observed here somewhat agree with other studies. The study had
several parameters impacted by a placebo effect, including the marker for oxidative
stress; this somewhat confounds the results. Other mentioned limitations
include a lack of phytochemical characterization of the teas and information
about subject diet. Despite these concerns, this study suggests that green tea
potentially decreases a risk for CVD.
This study was conducted as part of The Kakegawa
Study, which was supported by a research and development grant for projects promoting
new policies in agriculture, forestry, and fisheries from the Ministry of
Agriculture, Forestry and Fisheries, Japan (Tokyo, Japan).
—Amy C. Keller, PhD
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