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- Korean Red Ginseng (Panax ginseng, Araliaceae)
- Epithelial Ovarian Cancer
- Adjuvant Chemotherapy
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Date:
06-30-2018 | HC# 111758-595
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Re: Korean Red Ginseng May Reduce Genotoxicity and Improve Quality of Life in Patients with Epithelial Ovarian Cancer receiving Chemotherapy
Kim
HS, Kim M-K, Lee M, Kwon B-S, Suh DH, Song YS. Effect of red ginseng on
genotoxicity and health-related quality of life after adjuvant chemotherapy in
patients with epithelial ovarian cancer: a randomized, double blind,
placebo-controlled trial. Nutr. July 2017; 9(7):772. doi: 10.3390/nu9070772.
Epithelial
ovarian cancer (EOC) has no effective screening method for early detection, and
it is often detected at advanced states. As a consequence, the survival rate is
low. Patients diagnosed with EOC have a poor health-related quality of life
(HRQL), which is worsened by chemotherapy. Complementary and alternative
medicines are being evaluated to help improve HRQL in these patients. Korean
red ginseng (Panax ginseng, Araliaceae)
root contains ginsenosides that may reduce genotoxic effects of chemotherapy.
Also, studies show that Korean red ginseng may improve fatigue and cognition,
thereby improving quality-of-life. The purpose of this randomized, double-blind,
placebo-controlled study was to evaluate the effect of Korean red ginseng on
genotoxicity and HRQL in patients with EOC undergoing chemotherapy.
Women
(n = 30, mean age 52.9 years in the placebo group and 55.9 years in the ginseng
group) with EOC participated in this study from April 2012 to November 2014 at Seoul
National University Hospital in Seoul, Korea. Included patients were older than
20 years; received six cycles of adjuvant taxane- and platinum-based
chemotherapy after cytoreductive surgery; had a complete or partial response
after chemotherapy; and completed the treatment within 8 weeks prior to
entering the study. Excluded patients had a history of smoking, a chronic
disease, recurrent cancer requiring more intensive treatment, previous
radiotherapy, and a history of hypersensitivity to ginseng.
Patients
received either placebo or 3000 mg/day (2 capsules 3x/day) Korean red ginseng
(prepared for the study from 6-year-old root) for 12 weeks. At baseline and at
12 weeks, blood was drawn to evaluate toxicity (white blood cells [WBC],
hemoglobin, platelet counts, neutrophil counts, lymphocyte counts, alanine
aminotransferase [ALT] levels, aspartate aminotransferase [AST] levels,
bilirubin levels, alkaline phosphatase [ALP] levels, blood urea nitrogen [BUN],
and creatinine). Genotoxicity was evaluated by measuring binucleated cell (BN)
index and micronuclei (MN) yield. HRQL was evaluated using the European
Organization for Research and Treatment of Cancer QLQ-C30 (EORTC QLQ-C30), the Brief
Fatigue Inventory (BFI), the Brief Pain Inventory (BPI), the Hospital Anxiety
and Depression Scale (HADS), and the Sleep Scale from the Medical Outcome Study
(MOS-SS). Progression-free survival (PFS) was measured and defined as the time
from the date of diagnosis to the date of cancer recurrence. Overall survival
was measured and defined as the time from the date of diagnosis to the date of
cancer-related death or end of the study.
Baseline
characteristics were similar between groups (P > 0.05). Treatment compliance
was excellent, with > 90% compliance rate. There was no significant
difference for either group in the BN index (P > 0.05) when comparing the
beginning to the end of the trial. However, Korean red ginseng significantly
decreased MN yield from week 0 to 12 (P = 0.038). There
were no significant changes in either group for lymphocyte and platelet counts,
bilirubin, ALP, BUN, and creatinine levels (P > 0.05 for all). Both the Korean
red ginseng group and the placebo group had significant increases in WBC (P =
0.008 for both), neutrophils (P = 0.030 for both), and hemoglobin (P < 0.001
and P = 0.001, respectively). AST (P = 0.010) and ALT (P = 0.009) levels
significantly increased over time in the Korean red ginseng group but not the
placebo group. There were no significant differences between groups for the
incidence of any adverse events (AE; P = 1.000 for all). For the Korean red
ginseng group’s EROTC QLQ-C30 results, emotional score (P = 0.027), fatigue (P
= 0.012), nausea and vomiting (P = 0.004), and dyspnea (P = 0.021) scores were
significantly improved at week 12 compared with baseline. In contrast, the
placebo group did not have significant improvements on these same EROTC QLQ-C30
parameters (P > 0.05 for all).
On
the BFI, for the Korean red ginseng group, worst fatigue score (P = 0.026), interference
score (P = 0.014), and enjoyment of life score (P = 0.035) were significantly
improved at week 12 compared with baseline. In contrast, the placebo group did
not have significant changes on these BFI parameters (P > 0.05 for all). On
the HADS, anxiety was significantly lower at week 12 compared with baseline in
the Korean red ginseng group (P = 0.015), but not in the placebo group (P =
0.119). On the MOS-SS, daytime somnolence score was significantly improved at
week 12 compared with baseline in the Korean red ginseng group (P = 0.043), but
not in the placebo group (P = 0.342). There were no significant differences
between groups on mean PFS (P = 0.448) and mean overall survival(P = 0.478).
The
authors conclude that Korean red ginseng is safe and may reduce genotoxicity
and improve HRQL in patients with EOC receiving chemotherapy. The decrease in
MN in the Korean red ginseng group indicates that Korean red ginseng may reduce
additional genetic mutations. Low MN is related to improved survival in cancer
patients. The authors hypothesize that oxidative stress and inflammation
induced by chemotherapy may reduce HRQL, and Korean red ginseng may benefit the
patient by decreasing both.
The
limitations of this study are the small population size and relatively short
duration. Large-scale clinical studies are needed to better estimate the
effects of Korean red ginseng on many of these outcomes. The authors declare no
conflicts of interest.
—Heather S. Oliff,
PhD
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