Fixed Combinations of Licorice root and German Chamomile flower Published July 14, 1993
Name of Drug
Fixed combinations of licorice root and chamomile flower.
Composition of Drug
Fixed combinations consisting of:
Licorice root with herb corresponding to the monograph published May 6, 1985 ( B. Anz . p. 4953); Chamomile flower corresponding to the monograph published November 1, 1984 ( B. Anz . p. 13326);
as well as their preparations in effective dosage.
Pharmacological Properties, Pharmacokinetics, Toxicology
For preparations of licorice and chamomile, an antispasmodic action is documented. Chamomile has an antiphlogistic and wound healing effect.
Glycyrrhizic acid and the aglycone of glycyrrhizic acid enhance the healing of gastric ulcers, according to controlled, clinical studies. Pharmacological studies pertaining to the fixed combination are not available.
Clinical Data
Uses
For symptomatic treatment of irritated (nervous) stomach and simple gastric ulcers.
Contraindications
For a daily dosage up to 100 mg glycyrrhizin:
For a daily dosage of more than 100 mg of glycyrrhizin:
- Cholestatic liver disorders, liver cirrhosis, hypertonia, hypokalemia, severe kidney insufficiency, pregnancy.
Side Effects
For a daily dosage up to 100 mg glycyrrhizin:
For a daily dosage of more than 100 mg of glycyrrhizin:
- Extended use and higher dosages can cause mineralocorticoid effects, such as sodium and water retention, loss of potassium with high blood pressure, edema and hypokalemia with muscle weakness, and, in rare cases, myoglobinuria.
Interactions with Other Drugs
For a daily dosage up to 100 mg glycyrrhizin:
For a daily dosage of more than 100 mg of glycyrrhizin:
- Loss of potassium due to other medications, e.g., thiazide and loop diuretics, can be intensified. Loss of potassium increases the sensitivity to digitalis glycosides.
Dosage
Unless otherwise prescribed:
The individual combination partners must be present at the concentration of 50 - 75 percent of the daily dosage given in the individual monographs.
Mode of Administration
Comminuted herb and preparations for oral use.
Duration of Administration
Without medical advice, not longer than 4 - 6 weeks.
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