Fixed Combinations of Primrose root, Marshmallow root, and Anise seed

Fixed combinations of primrose root [ Primula , not Oenothera (evening primrose)], marshmallow root, and anise seed.  

Fixed combinations consisting of:

Primrose root corresponding to the monograph published April 11, 1988;
Marshmallow root corresponding to the monograph published January 5, 1989;
Anise seed corresponding to the monograph published April 11, 1988;

as well as their preparations in effective dosage.  

Catarrh of the upper respiratory tract and resulting dry cough.  

Hypersensitivity to anise and anethole.  

Occasionally allergic reactions involving skin, respiratory tract and gastrointestinal tract.  Isolated stomach discomforts and nausea can occur.  

Note:The absorption of other, simultaneously administered medicines can be delayed.  

Unless otherwise prescribed:

Marshmallow root must be present in the dosage given in its monograph.  

Primrose root and anise must be at the concentration of 50 - 75 percent of the daily dosage given in the individual monographs.  

Deviating dosages must be justified specifically for the preparation.  

Liquid and solid forms of preparations for oral use.  

An expectorant effect is documented for primrose root and anise seed; in addition, a secretolytic action is shown for primrose root.  Anise has an antibacterial and mild antispasmodic action, marshmallow root has a soothing action and inhibits ciliary activity in vitro.  Pharmacological experiments for the fixed combinations are not available.