Squill
Scillae bulbus
Meerzwiebel
Published August 21, 1985; Revised March 2, 1989
Name of Drug
Scillae bulbus, squill, sea onion.
Composition of Drug
Squill consists of the sliced, dried, fleshy middle scales of the onion of the white variety of Urginea maritima (L.) Baker [Fam. Liliaceae], harvested at flowering season, as well as their preparations in effective dosage.
Squill contains glycosides of the bufadienolide type. Main glycosides are scillaren A and proscillaridin A, flavonoids and anthocyanins.
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Uses
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Milder cases of heart insufficiency, also for diminished kidney capacity.
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Contraindications
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Therapy with digitalis glycosides, potassium deficiency.
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Side Effects
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Nausea, vomiting, stomach disorders, diarrhea, irregular pulse.
Interactions with Other Drugs
Increase of effectiveness and thus also of side effects by simultaneous administration of quinidine, calcium, saluretics, laxatives and extended therapy with glucocorticoids.
Dosage
Unless otherwise prescribed:
Average daily dosage:
- 0.1 - 0.5 g of standardized sea onion; powder;
- equivalent preparations.
Mode of Administration
Comminuted drug and other galenical preparations for internal use.
Actions
Positively inotropic on myocardial work capacity
Negatively chronotropic
"Economizing" heart action
Lowering increased, left ventricular diastolic pressure and pathologically elevated venous pressure.
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